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Home » Authors » W. Todd Penberthy

W. Todd Penberthy

Articles

ARTICLES

Adenovirus cells

"Foundational" research shows early gene therapy prevents Angelman syndrome

Oct. 30, 2020
By W. Todd Penberthy
Scientists working at the University of North Carolina, Chapel Hill reported in the Oct. 21, 2020, issue of Nature on the successful development of a one-time specific sequence-directed gene therapy approach using the combination of AAV with CRISPR technology that successfully prevented the presentation of Angelman syndrome throughout the lifetime of a mouse model.
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Lung cancer illustration

Lipid metabolism controls lung cancer metastasis, not just diseases like atherosclerosis

Sep. 30, 2020
By W. Todd Penberthy
Researchers working at the Jackson Laboratory Cancer Center reported in the September 21, 2020, issue of Nature Immunology that breast cancer cells induced neutrophils to accumulate lipids, which were transported to metastatic tumor cells through a macropinocytosis pathway, thus fueling the metastatic potential of tumor cells with lipids.
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Man adding piece to brain
The long and short of it

Oncogene Ras affects memory consolidation

Jan. 21, 2020
By W. Todd Penberthy
Remember how Ras is a frequently mutated oncogene in solid tumors? Well, it turns out Ras plays a role in those memories, too. In the Jan. 13, 2020, online issue of the Proceedings of the National Academy of Sciences, scientists at the Scripps Research Institute in Juniper, Fla., reported on the discovery that Ras signals through Raf and then Rho kinase to control whether memory is short- or long-term.
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Man adding piece to brain
The long and short of it

Oncogene Ras affects memory consolidation

Jan. 17, 2020
By W. Todd Penberthy
Remember how Ras is a frequently mutated oncogene in solid tumors? Well, it turns out Ras plays a role in those memories, too. In the Jan. 13, 2020, online issue of the Proceedings of the National Academy of Sciences, scientists at the Scripps Research Institute in Juniper, Fla., reported on the discovery that Ras signals through Raf and then Rho kinase to control whether memory is short or long-term.
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Cells lining trachea

Targetable dopamine receptor influences childhood-onset asthma

Nov. 26, 2019
By W. Todd Penberthy
Children are more susceptible to developing allergic asthma than adults. An estimated 6 million children have allergic asthma, making asthma one of the most common long-term diseases of childhood. Asthma is potentially life-threatening, yet there is no cure, rather only management of symptoms. Progress in understanding the disease was reported in the Dec 17, 2019, issue of Immunity.
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High oxygen levels may be issue in Leigh syndrome

Aug. 16, 2019
By W. Todd Penberthy
Birth defects in mitochondrial genes can lead to devastating pediatric disorders with death within a year of birth, and when the dysfunction is milder it can lead to various types of degenerative conditions, including neurodegeneration.
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HMP delivers insights into microbiome changes, stability

June 6, 2019
By W. Todd Penberthy

HMP at 10 delivers insights into microbiome changes, and stability

May 30, 2019
By W. Todd Penberthy
Three new studies conducted as part of the second phase of the Human Microbiome Project (HMP) could lead to improvements in the risk prediction, identification and classification of the conditions they are investigating.
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Phage therapy treats drug-resistant mycobacterial infection

May 17, 2019
By W. Todd Penberthy

Phage therapy treats drug-resistant mycobacterial infection

May 10, 2019
By W. Todd Penberthy
In a first, researchers were able to use a genetically modified specific lytic phage strain to stop an otherwise generally lethal drug-resistant Mycobacterium abscessus infection in a cystic fibrosis patient after persistent infections, as reported in the May 8, 2019, issue of Nature Medicine.
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View All Articles by W. Todd Penberthy

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