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Home » Authors » Randy Osborne

Articles by Randy Osborne

Breast cancer illustration

Second Probody still bubbling as Cytomx back-burners CX-2009

July 7, 2022
By Randy Osborne

Attention has turned to Cytomx Therapeutics Inc.’s CX-2029 candidate after the company held up its program with the CD166-directed antibody-drug conjugate CX-2009, based on phase II data in patients with hormone receptor-positive/HER2-non-amplified breast cancer.


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Abdominal pain illustration

In segmentation of Market, long-untreated UC patients may have skewed AMT’s phase II

July 6, 2022
By Randy Osborne

Treating sooner in the disease course – “hit them hard, hit them early,” as CEO Tahir Mahmood put it – may change outcomes for the better with AMT-101, the candidate from Applied Molecular Transport Inc. (AMT) tested in a combo trial against ulcerative colitis (UC), officials said during a conference call with investors.


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Black and white arrows merging into one

Syros finds Tyme right for merger; $130M financing, too

July 5, 2022
By Randy Osborne
The Hail Mary pass by Syros Pharmaceuticals Inc. – shares of which have dwindled severely since Jan. 3 – foreseen by some on Wall Street, came in the form of a $130 million financing and the merger with Tyme Technologies Inc., bringing in-house pipeline assets as well as net cash in a deal that, after accounting for wind-down and transaction expenses, is worth about $60 million.
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Hand pain

The long and short of it: Astria may bring dosing upside to HAE with new kallikrein inhibitor

July 1, 2022
By Randy Osborne
Recently published real-world data with Firazyr (icatibant), the selective B2 bradykinin receptor antagonist from Takeda Pharmaceutical Co. Ltd. to treat acute hereditary angioedema (HAE) attacks, trained a spotlight on the space, where a handful of players compete. Among the prospects is the early stage but intriguing Star-0215 from Astria Therapeutics Inc., which could be the next advance in the kallikrein-inhibitor class.
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Handshake dollar sign

Blueprint roars back at bear market, nails down $1.25B financing deals

June 30, 2022
By Randy Osborne

Blueprint Medicines Corp. CFO Mike Landsittel called his firm’s potential $1.25 billion financing deals with Sixth Street and Royalty Pharma “once in a lifetime” arrangements that came at the end of a competitive process in a formidable cash environment.


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Man scratching arm

Skin-tight race in prurigo nodularis as Wall Street refracts Trevi’s PRISM data

June 29, 2022
By Randy Osborne
Trevi Therapeutics Inc. took its place among several late-stage contenders by scoring a win in prurigo nodularis in the form of positive data from the 360-participant, phase IIb/III Pruritus Relief through Itch-Scratch Modulation, or PRISM, trial with oral Haduvio (nalbuphine extended release).
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Tazverik product image

Ipsen still in buying mode after $247M Epizyme takeover; bigger deals ahead?

June 27, 2022
By Randy Osborne
After its $247 million acquisition of Epizyme Inc., Ipsen SA will continue to shop for M&A prospects, said Ipsen CEO David Loew, noting that “the [company’s] firepower has not been absorbed in a significant fashion by this deal,” and the firm might undertake a larger transaction next time in oncology, rare diseases, or neurology.
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Limb exam

Exon skipper still mobile in DMD, Sarepta gassed up for speedy answers to clinical hold

June 24, 2022
By Randy Osborne
Sarepta Therapeutics Inc. aims to resolve “very quickly” the clinical hold placed by the U.S. FDA on SRP-5051 (vesleteplirsen) for Duchenne muscular dystrophy (DMD), said Louise Rodino-Klapac, chief scientific officer.
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Uniqure reassures with full-year low-dose data in HD; efficacy ahead with gene therapy?

June 23, 2022
By Randy Osborne
Uniqure NV rolled out stock-pleasing safety and biomarker data from 10 patients enrolled in the low-dose cohort of the ongoing phase I/II trial with AMT-130 for the treatment of Huntington’s disease (HD), but investors must wait for details on MRI scans. “We have communicated that we will discuss the MRI findings in the middle of next year,” CEO Matt Kapusta told investors during a conference call. “That’s all I can say.”
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Phase II fizzle in AD hammers Athira shares, unblinding of phase III mulled

June 22, 2022
By Randy Osborne
Shares of Athira Pharma Inc. (NASDAQ:ATHA) plunged almost 66.3%, or $5.60, to close at $2.85 on June 22 after the company disclosed top-line results from its exploratory phase II study with fosgonimeton (ATH-1017, fosgo) in mild-to-moderate Alzheimer’s disease (AD).
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