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Home » Authors » Randy Osborne

Articles by Randy Osborne

T cells

Yeeha at EHA: Sierra’s two-in-one approach with momelotinib welcomed in MF

July 7, 2021
By Randy Osborne
The whopper June buyout of by Morphosys AG of Constellation Pharmaceuticals Inc. brought renewed attention to myelofibrosis (MF) and other players in the space, such as Sierra Oncology Inc.
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Stock merger illustration

Biosight just right for Advaxis praxis; merger deal sealed

July 6, 2021
By Randy Osborne
Advaxis Inc.’s long journey is ending happily by way of a merger with Biosight Ltd. that leaves the new firm with $50 million to help advance aspacytarabine (BST-236), a prodrug of cytarabine for acute myeloid leukemia and myelodysplastic syndromes.
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Brain and neural networks

Alector selector dials up GSK in potential $2.2B progranulin deal

July 2, 2021
By Randy Osborne
Alector Inc. Chief Operating Officer Shehnaaz Suliman said her company’s deal with Glaxosmithkline plc (GSK) – worth as much as $2.2 billion – “allows us to expand into indications that we have been quite thoughtful about doing, but in a more expeditious manner. This is really an opportune time to continue to explore the biology of these programs across multiple indications.”
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Kidneys

No filter: Diamedica kidney picture clouded after interim phase II viewing

June 29, 2021
By Randy Osborne
Diamedica Therapeutics Inc.’s chief medical officer, Harry Alcorn, said that “due to the complexity [of diabetic kidney disease (DKD)], there's not a clear answer” as to why such patients did less well in the company’s Redux phase II trial with DM-199 (recombinant human tissue kallikrein 1 [KLK1]). “But I wouldn't say that there wasn't a response in the DKD group,” he said, citing upside in 30% of subjects.
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Editor in chief? Street reads proof from Intellia’s ATTR phase I

June 28, 2021
By Randy Osborne
CEO John Leonard said Intellia Therapeutics Inc. plans “to share information on a cohort-by-cohort basis, so we get a consistent readout” and, as the year goes on, longer-term follow-up findings will emerge from the phase I trial with the company’s lead in vivo genome editing candidate, NTLA-2001.
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Pills and bottle

Fulcrum set to pivot in FSHD? No DUX4 score but secondary goals extolled

June 25, 2021
By Randy Osborne
Fulcrum Therapeutics Inc.’s phase IIb data with losmapimod in facioscapulohumeral muscular dystrophy (FSHD) brought renewed hope for patients in what historically has proved a challenging therapeutic space. Though the firm’s oral p38 mitogen-activated protein kinase inhibitor missed its primary biomarker endpoint – changes in DUX4-driven gene expression – other indicators of benefit in the study called ReDUX4 painted a bright picture.
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ARC of a driver: TIGIT win would boost shared dreams, spur Gilead to domvanalimab option – but not yet

June 24, 2021
By Randy Osborne
Wall Street must wait a while longer to find out if Gilead Sciences Inc. will exercise its $275 million option for Arcus Biosciences Inc.’s TIGIT binder, domvanalimab. Meanwhile, investors took heart from an optimistic – albeit vague – interim report on the phase II ARC-7 trial.
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How Abata new strategy in non-relapsing MS? Third Rock leads $95M series A

June 23, 2021
By Randy Osborne
CEO Samantha Singer said Abata Therapeutics Inc. “spent a considerable amount of time finding the right indication” for its approach, which deploys autologous regulatory T cells (Tregs) made to express T-cell receptors (TCRs). That disease is progressive, non-relapsing multiple sclerosis (MS). “We’re going to be able to succeed with these patients where other options have failed,” she told BioWorld.
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Laptop displaying FDA logo

Same as it ever was: FDA docs reaffirm how Aduhelm got here

June 23, 2021
By Randy Osborne
More than two weeks after the FDA gave its go-ahead to Biogen Inc.’s Aduhelm (aducanumab), controversy still rages over the accelerated approval as well as the price for the anti-amyloid beta monoclonal antibody for Alzheimer’s disease (AD). Embattled U.S. regulators made the uncommon move of releasing documents – with more due to be made public later – that show the internal deliberations that led to Aduhelm’s clearance.
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Antibodies attacking cancer cell

BMS, Eisai join forces for phase I ADC in potential $3B-plus deal

June 22, 2021
By Randy Osborne
Bristol Myers Squibb Co. and Eisai Co. Ltd. inked a potential $3.1 billion agreement to co-develop and co-commercialize the antibody-drug conjugate MORAb-202 for advanced solid tumors.
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