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Home » Authors » Randy Osborne

Randy Osborne

Articles

ARTICLES

Acadia moment of Clarity ends MDD push with Nuplazid, DRP under FDA review

July 23, 2020
By Randy Osborne
Testing Nuplazid (pimavanserin) against major depressive disorder (MDD), Acadia Pharmaceuticals Inc. became the latest to fail in the indication as the company unveiled top-line results from the 298-patient phase III effort called Clarity.
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Function call brings GV to Encoded program in $135M series D

July 22, 2020
By Randy Osborne
Chief Business Officer David McNinch told BioWorld that South San Francisco-based Encoded Therapeutics Inc.’s $135 million from an oversubscribed series D financing follows by about a year the hefty series C round that “helped us get the [lead gene therapy] program poised to its current stage, which is IND-enabling studies.” The asset, ETX-101 for SCN1A-positive Dravet syndrome (DS), is expected to enter human trials next year.
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Some Assembly required: Beigene finds HBV partner in $540M deal

July 21, 2020
By Randy Osborne
The two-year standstill provision in Assembly Biosciences Inc.’s potential $540 million pact with Beigene Ltd. to advance hepatitis B virus (HBV) therapies was “highly negotiated,” said Jason Okazaki, Assembly’s chief legal and business officer.
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Some Assembly required: Beigene finds HBV partner in $540M deal

July 20, 2020
By Randy Osborne
The two-year standstill provision in Assembly Biosciences Inc.’s potential $540 million pact with Beigene Ltd. to advance hepatitis B virus (HBV) therapies was “highly negotiated,” said Jason Okazaki, Assembly’s chief legal and business officer.
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Phage bids increasing Locus of interest as Armata cuts water

July 17, 2020
By Randy Osborne
Armata Pharmaceuticals Inc.’s recent $15 million award for a three-year program from the U.S. Department of Defense to partially fund a phase Ib/II study added to the already growing resurgence of notice for phage-based therapeutics, with even big pharma starting to take heed.
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IPO, coins, upward arrow

Anton check-off: Long story short, Relay IPO proves Dynamo at $400M

July 16, 2020
By Randy Osborne
Robust financial markets continue to fuel the industry despite gloom over the COVID-19 pandemic, with Relay Therapeutics Inc. pricing its upsized, 20 million-share IPO at $20 per unit to reap $400 million.
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3D illustration of virus with RNA inside

Shoot (up) the messenger: COVID-19 mRNA vaccine prospects bearing not-bad news

July 15, 2020
By Randy Osborne
An editorial yesterday in The New England Journal of Medicine (NEJM) marveled that “the world has now witnessed the compression of six years of work into six months,” and went on to ask the question that’s on everyone’s pandemic-wrenched mind: “Can the vaccine multiverse do it again, leading to a reality of a safe, efficacious COVID-19 vaccine for the most vulnerable in the next six [months]?”
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Coronavirus, lungs, hand holding stethoscope

India ink: Equillium shares deep in the black after COVID-19 data from partner

July 14, 2020
By Randy Osborne
Although details are yet to come, Equillium Inc.’s chief medical officer, Krishna Polu, told BioWorld that the company will move “urgently and expeditiously” to set up another experiment testing itolizumab in COVID-19 now that Bangalore, India-based partner Biocon Ltd. has unveiled positive phase II results with the CD6-targeting agent. Shares of Equillium (NASDAQ:EQ) closed at $26.50, up $23.31, or 731%, after trading as high as $27.05. “We recognize we have to do a robust study,” said Bruce Steel, CEO of the La Jolla, Calif.-based firm. Talks with the FDA about design come next, but the clinical bid will “very likely include sites outside the U.S.,” where the need is high and where there is “somewhat less competition for patients,” he said.
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Tumor necrosis factor (TNF), a cytokine involved in inflammation processes

AD not in-‘soluble’ after all? Street likes Inmune’s bet on next-gen TNF

July 14, 2020
By Randy Osborne
Inmune Bio Inc. CEO Raymond Tesi told BioWorld his firm is taking an “oncology-style” approach to Alzheimer’s disease (AD) as the firm tests next-generation tumor necrosis factor (TNF) inhibitor XPro-1595 against neuroinflammation.
Read More
Coronavirus, lungs, hand holding stethoscope

India ink: Equillium shares deep in the black after COVID-19 data from partner

July 13, 2020
By Randy Osborne
Although details are yet to come, Equillium Inc.’s chief medical officer, Krishna Polu, told BioWorld that the company will move “urgently and expeditiously” to set up another experiment testing itolizumab in COVID-19 now that Bangalore, India-based partner Biocon Ltd. has unveiled positive phase II results with the CD6-targeting agent.
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View All Articles by Randy Osborne

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