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Home » Authors » Randy Osborne

Randy Osborne

Articles

ARTICLES

Cancer cells

Making the circuit at JPM, Relay galvanized for big year ahead in PI3Ka, FGFR2

Jan. 10, 2024
By Randy Osborne
Among the firms updating progress at the J.P. Morgan Healthcare Conference (JPM) in San Francisco this week was Relay Therapeutics Inc., coming off a $30 million financing to boost its Dynamo platform and candidates.
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GSK House London

TSLP approach draws GSK to Aiolos buyout: $1B up front

Jan. 9, 2024
By Randy Osborne
GSK plc is plunking down $1 billion cash to take over Aiolos Bio Inc., with the promise of as much as $400 million in regulatory milestone payments along with tiered royalties. The deal gives London-based GSK asthma candidate AIO-001, a phase II-ready, long-acting antibody that binds to the human thymic stromal lymphopoietin (TSLP) ligand to inhibit TSLP signaling and relieve inflammation. GSK said AIO-001 could redefine the standard of care in asthma via the prospect of dosing every six months.
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Merck spears Harpoon to enter DLL3 waters in $680M deal

Jan. 8, 2024
By Randy Osborne
Merck & Co. Inc.’s deal to pay $23 in cash for Harpoon Therapeutics, bringing the equity value to about $680 million, further invigorated the delta-like ligand 3 (DLL3) development zone, where Amgen Inc. enjoys a lead with its prospect tarlatamab in the same class. DLL3 is an inhibitor ligand of the Notch pathway associated with tumorigenesis.
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3D illustration of B-cell lymphoma

Allogene first-line LBCL Foresight questioned, cheered as strategy shifts

Jan. 5, 2024
By Randy Osborne
Allogene Therapeutics Inc.’s decision to preferentially pursue first-line treatment of large B-cell lymphoma (LBCL) with CAR T cemacabtagene ansegedleucel (cema-cel, previously known as ALLO-501A) met mixed reviews on Wall Street.
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Better CAR T therapies the focus of $1.44B Umoja, Abbvie deal

Jan. 4, 2024
By Randy Osborne
Umoja Biopharma Inc.’s gene delivery platform that combines a third-generation lentiviral vector gene approach with a novel T-cell targeting and activation surface complex brought Abbvie Inc. to the table for a pair of deals that could be worth as much as $1.44 billion.
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Dyne proves Force to be reckoned with in DM1, DMD as phase I/II validate platform

Jan. 3, 2024
By Randy Osborne
With positive initial phase I/II data in hand from two trials, Dyne Therapeutics Inc. plans to report more findings and start enrolling registrational cohorts in both studies by the end of this year for DYNE-101 in myotonic dystrophy type 1 (DM1) and a study called Deliver with DYNE-251 in Duchenne muscular dystrophy (DMD) who are amenable to exon 51 skipping.
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Brain and encephalography

Downhill from here? DEE win has Longboard cruising toward phase III

Jan. 2, 2024
By Randy Osborne
Longboard Pharmaceuticals Inc.’s positive – and then some – phase Ib/IIa top-line data with 5-HT2C receptor superagonist bexicaserin (LP-352) in developmental and epileptic encephalopathies (DEEs) sparked Wall Street speculation about competitive odds as well as the shape of the firm’s upcoming phase III effort.
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Top Trends Therapeutics, pill, syringe

Industry learning its ADCs better and better as deals abound

Dec. 29, 2023
By Randy Osborne
Pharma-biotech pairings continued apace in the antibody-drug conjugate (ADC) space, with 2023 capped by Legochem Biosciences Inc. signing a $1.7 billion licensure deal with Johnson & Johnson arm Janssen Biotech Inc. for the former’s Trop2-directed compound, the second-biggest Korean technology transfer agreement.
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Top Trends Therapeutics, pill, syringe

Industry, FDA mindset coming around to psychedelics

Dec. 27, 2023
By Randy Osborne
The long, strange and nowhere-near-concluded trip taken by psychedelic drugs as a therapeutic modality continued in 2023, with regulators in the U.S. and Europe – and, perhaps in greater numbers, investors – warming to prospects in a space that once drew only laughter.
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Adenovirus cells

Allovir dumps triple-phase III posoleucel for futility

Dec. 22, 2023
By Randy Osborne
What Piper Sandler analyst Christopher Raymond called the “shocking” decision by Allovir Inc. to scrap development of posoleucel – which had advanced to three phase III trials – for all indications sent shares of the firm (NASDAQ:ALVR) in a tailspin, closing Dec. 22 at 76 cents, down $1.56, or 67%.
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