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Home » Authors » Randy Osborne

Randy Osborne

Articles

ARTICLES

A Star is born as new SIRP player aims to Electra-fy rare disease

Feb. 16, 2022
By Randy Osborne
Star Therapeutics Inc. emerged from stealth mode to tell the world about its approach to drug discovery and development in rare diseases, and to spin out Electra Therapeutics Inc., the first in a projected family of companies.
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TYK2 click-through? Other players watch, wait for BMS PDUFA date

Feb. 14, 2022
By Randy Osborne

As investors await the Sept. 10 PDUFA date for deucravacitinib from Bristol Myers Squibb Co. (BMS) in psoriasis, handicappers continue to weigh the odds of other tyrosine kinase 2 (TYK2) inhibitors, and ponder what a regulatory victory – or defeat – might mean for the space.


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Blood pressure cuff

Cincor swim? Pressure’s on, but Street likes aldosterone ‘pipeline in a pill’

Feb. 11, 2022
By Randy Osborne
Cincor Pharma Inc.’s IPO at the start of the year underlined hopes for a new way to attack treatment-resistant hypertension and related diseases, as the Boston-based firm touted what one analyst called it ‘pipeline in a pill,” CIN-107, which selectively targets aldosterone synthase to lower aldosterone levels, in turn knocking down blood pressure.
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Petri dish and capsules
Newco news

Hard DRIVE for virus fixes: Altesa, Emory take on global threats

Feb. 10, 2022
By Randy Osborne
Altesa Biosciences Inc. CEO Brett Giroir called the firm’s scientific co-founders George Painter and Dennis Liotta “the most important developers of drugs against viruses on the planet, and probably in history.” Giroir’s remarks came as the College Park, Ga.-based firm launched to develop and commercialize new antiviral drugs against common respiratory bugs such rhinovirus and parainfluenza, as well as vector-borne threats such as Dengue fever, yellow fever, Zika and Powassan.
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Endometrial/uterine cancer illustration

Karyopharm plays ‘wild’ card with Xpovio in EC; pair of jacks or better?

Feb. 8, 2022
By Randy Osborne
Wall Street nicked shares of Karyopharm Therapeutics Inc. after the firm offered top-line results from the 263-subject phase III study with Xpovio (selinexor) in advanced or recurrent endometrial cancer (EC). Shares (NASDAQ:KPTI) closed at $8.19, down $2.05, or 20%, having dropped as low as $7.66.
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Lung illustration

$101M series B proves Endeavor worthy in IPF, cancer

Feb. 7, 2022
By Randy Osborne
Endeavor Biomedicines Inc.’s $101 million series B round will let the firm forge ahead with ENV-101 (taladegib), a small-molecule inhibitor of the PTCH1 receptor in the Hedgehog signaling pathway, for cancer and idiopathic pulmonary fibrosis (IPF), as well as ENV-201, described as a potentially best-in-class small-molecule inhibitor of ULK1/2 in KRAS-driven cancers.
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Woman in crowd with anxiety

Social climbers: Bionomics, Vistagen strive for heights in SAD

Feb. 4, 2022
By Randy Osborne
Bionomics Ltd.’s U.S. debut last December, when the firm raised about $23 million through the sale of American depositary shares, called new attention to the Australian firm and its prospects in social anxiety disorder (SAD) and post-traumatic stress disorder (PTSD).
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CDK9 iron swings hard; lofty goals in solid, hematologic cancer

Feb. 3, 2022
By Randy Osborne
The dosing by Vincerx Pharma Inc., in mid-December of last year, of the first patient in the phase I study with VIP-152 marked the second experiment begun by the company in 2021, and added oomph to the already-growing renewal of interest in CDK9 as a therapeutic target.
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Woman and 3D brain

Street sweats Rett bet; Anavex endpoints out of joint?

Feb. 1, 2022
By Randy Osborne
Anavex Life Sciences Corp. reported top-line data from the 33-subject phase III study with Anavex 2-73 (blarcamesine) in adult females with Rett syndrome, turning up a statistically significant improvement over placebo for the primary efficacy endpoint as well as for all the secondary efficacy endpoints. The sigma-1 receptor activator, given as a once-daily, oral liquid, proved well-tolerated, too, with good compliance by patients, Anavex said.
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Oric marches on post-ASH as others trod adenosine pathway with CD73s

Jan. 28, 2022
By Randy Osborne
Oric Pharmaceuticals Inc.’s preclinical data at last December’s meeting of the American Society of Hematology didn’t please everyone but infused the CD73 drug space with more rationale for the target, and a number of other prospects continue to move through pipelines. Previous early stage findings also have suggested favorable knockdown of adenosine in comparison to Astrazeneca plc’s oleclumab and Arcus Biosciences Inc.’s small molecule, AB-680, also known as quemliclustat. Companies developing CD73 therapies also include Corvus Pharmaceuticals Inc. and Novartis AG.
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View All Articles by Randy Osborne

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