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Home » Authors » Randy Osborne

Randy Osborne

Articles

ARTICLES

Topaz data crystallizing in SMA, Scholar Rock not Dragon its feet

Oct. 27, 2020
By Randy Osborne
Shares of Cambridge, Mass.-based Scholar Rock Holding Corp. closed Oct. 27 at $30.02, up $16.30, or 119%, on positive six-month interim analysis results from the Topaz phase II trial with inhibitor of myostatin activator SRK-015 in type 2 and type 3 spinal muscular atrophy, and CEO Tony Kingsley pointed to “a rich cascade of data ahead of us.”
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FDA clears Kala DED therapy; stock sinks as payer, pandemic concerns aired

Oct. 27, 2020
By Randy Osborne
Kala Pharmaceuticals Inc.’s anticipated win with Eysuvis (loteprednol etabonate ophthalmic suspension) 0.25% for the short-term (up to two weeks) treatment of the signs and symptoms of dry eye disease (DED) didn’t help shares (NASDAQ:KALA), which closed Oct. 27 at $6.28, down $1.44, or 18.7%, on word of the FDA approval.
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Fee FAAH fo’ Springworks as $410M Jazz deal proves mechanism no has-bean

Oct. 26, 2020
By Randy Osborne
The fatty acid amide hydrolase (FAAH) inhibitor space may seem, in the words of one analyst, “historically a graveyard,” but that didn’t keep Jazz Pharmaceuticals plc from buying Springworks Therapeutics Inc.’s program with a plan to take aim first at post-traumatic stress disorder (PTSD) and associated symptoms.
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M&A cityscape

Not-little Orphan ante, more HCU Warbucks ahead in $517M Retrophin deal

Oct. 23, 2020
By Randy Osborne
CEO Eric Dube said Retrophin Inc. will “share more [about clinical development plans] once the deal has closed” in the fourth quarter of this year and Orphan Technologies Ltd. belongs to his firm, which has seen only animal data so far with OT-58, an enzyme replacement therapy (ERT) for classical homocystinuria (HCU).
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Hospital patient wearing pulse oximeter

As WHO findings disappoint, COVID-19 developers stand in Solidarity

Oct. 20, 2020
By Randy Osborne
The large-scale failure of a handful of drugs repurposed for COVID-19 hasn’t slowed efforts to find existing – and new – therapies as well as vaccines that can fight the pandemic, with research updates continuing to roll out.
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Redeeming qualities in PTSD phase II – for Aptinyx shares, too

Oct. 20, 2020
By Randy Osborne
Aptinyx Inc. CEO Norbert Riedel said the design is unclear of the pivotal trial due next year with the N-methyl-D-aspartate (NMDA) receptor modulator NYX-783 in post-traumatic stress disorder (PTSD), as fine points must be hashed out with the FDA.
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Nectin-4 case built for two? Bicycle puts pedal to the mettle

Oct. 19, 2020
By Randy Osborne
Cambridge, U.K.-based Bicycle Therapeutics plc’s phase I dosing about a month ago of its first patient with nectin-4-targeting BT-8009 put the company on the road to hoped-for success by pursuing the same mechanism of action as Padcev (enfortumab vedotin-ejfv), the antibody-drug conjugate (ADC) from Astellas Pharma Inc. and Seagen Inc.
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Hospital patient wearing pulse oximeter

As WHO findings disappoint, COVID-19 developers stand in Solidarity

Oct. 16, 2020
By Randy Osborne
The large-scale failure of a handful of drugs repurposed for COVID-19 hasn’t slowed efforts to find existing – and new – therapies as well as vaccines that can fight the pandemic, with research updates continuing to roll out.
Read More

Large COVID-19 Solidarity study finds repurposed drugs don’t work

Oct. 16, 2020
By Randy Osborne
Brain with puzzle piece removed

Anavex reaches pivot(al) point with sigma-1 program in PDD

Oct. 15, 2020
By Randy Osborne
CEO Christopher Missling said New York-based Anavex Life Sciences Corp. is still deciding on the dose for the pivotal study with Anavex2-73 (blarcamesine) in Parkinson’s disease dementia (PDD), and called the phase II findings “just the first data run,” about which the firm “wanted to immediately inform shareholders.”
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View All Articles by Randy Osborne

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