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Home » Authors » Anette Breindl

Articles by Anette Breindl

Illustration of brain degeneration
Neurology/psychiatric

EAN 2024: Better diagnoses are shared dream of neurodegeneration researchers

July 1, 2024
By Anette Breindl
“Do dreams predict the future?” Abidemi Otaiku asked his audience at the 10th Congress of the European Academy of Neurology, currently being held in Helsinki. Most audience members, being hard-boiled scientists, did not believe they did. But Otaiku, whose work won the award for best clinical abstract at the conference, presented data indicating that in some cases, they can.
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Sunrise in a desert with sand dunes
Inflammatory

Study gives insight into five inflammatory diseases, and the noncoding genome

June 25, 2024
By Anette Breindl
A recent paper has identified the enhancer ETS2, located in a so-called gene desert, as a contributor to five separate immune disorders. It also showed that one of ETS2’s target genes mediating this inflammation was the eminently druggable MEK, a kinase that is the target of the FDA-approved inhibitors Mekinist (trametinib, GSK plc), Mektovi (binimetinib, Array Biopharma Inc.), Cotellic (cobimetinib, Roche Holding AG) and Koselugo (selumetinib, Astrazeneca plc/Merck & Co. Inc.).
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Immunofluorescence image shows macrophages in human clear cell renal cell carcinoma

Expressed on macrophages, PD-1 has role in 'obesity paradox'

June 18, 2024
By Anette Breindl
High weight is associated with a greater risk of developing many cancers, and with an increased risk of metastasis. But in some cancers such as renal cell carcinoma, it is also associated with better survival and a better response to immunotherapies in particular.
Read More
Immunofluorescence image shows macrophages in human clear cell renal cell carcinoma

Expressed on macrophages, PD-1 has role in 'obesity paradox'

June 14, 2024
By Anette Breindl
High weight is associated with a greater risk of developing many cancers, and with an increased risk of metastasis. But in some cancers such as renal cell carcinoma, it is also associated with better survival and a better response to immunotherapies in particular.
Read More
Immunofluorescence image shows macrophages in human clear cell renal cell carcinoma
Cancer

Expressed on macrophages, PD-1 has role in 'obesity paradox'

June 13, 2024
By Anette Breindl
High weight is associated with a greater risk of developing many cancers, and with an increased risk of metastasis. But in some cancers such as renal cell carcinoma, it is also associated with better survival and a better response to immunotherapies in particular.
Read More
Cancer cell, DNA illustration
Cancer

Immune response to germline variants shapes breast cancer subtypes

June 7, 2024
By Anette Breindl
Germline variants that did not affect gene function nevertheless affected multiple aspects of breast cancer risk, via their visibility to the immune system and its reactions. Perhaps most surprisingly, the same genetic constellations that were protective at the very earliest stage of breast cancer, stage 0 or ductal carcinoma in situ, were associated with worse outcomes once a tumor had become invasive.
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Cancer cell, DNA illustration
Cancer

Immune response to germline variants shapes breast cancer subtypes

May 31, 2024
By Anette Breindl
Germline variants that did not affect gene function nevertheless affected multiple aspects of breast cancer risk, via their visibility to the immune system and its reactions. Perhaps most surprisingly, the same genetic constellations that were protective at the very earliest stage of breast cancer, stage 0 or ductal carcinoma in situ, were associated with worse outcomes once a tumor had become invasive.
Read More
Microscopic image showing histology of a glioblastoma multiforme
Cancer

TREM2 is immunoprotective in glioblastoma

May 30, 2024
By Anette Breindl
Chinese investigators have reported that high levels of triggering receptor expressed on myeloid cells 2 (TREM2) expression, which are immunosuppressive in multiple solid tumors, were protective in glioblastoma multiforme (GBM). The findings were published May 23, 2024, in Cancer Cell.
Read More
Illustration of Epstein-Barr virus particles

Inhibiting metabolic enzyme prevents EBV-driven disease

May 28, 2024
By Anette Breindl
Treatment with indoleamine dioxygenase-1 (IDO1) inhibitors reduced both viremia and B cell transformation in animal models of post-transplant lymphoproliferative disorder (PTLD), while IDO1 up-regulation occurred in patients who would go on to develop PTLD. The findings, which were reported in the May 24, 2024, issue of Science by researchers from the University of Basel and the University Hospital Basel, point to new ways to predict, prevent and treat complications of Epstein-Barr virus (EBV) infection.
Read More
Illustration of Epstein-Barr virus particles
Immune

Inhibiting metabolic enzyme prevents EBV-driven disease

May 24, 2024
By Anette Breindl
Treatment with indoleamine dioxygenase-1 (IDO1) inhibitors reduced both viremia and B cell transformation in animal models of post-transplant lymphoproliferative disorder (PTLD), while IDO1 up-regulation occurred in patients who would go on to develop PTLD. The findings, which were reported in the May 24, 2024, issue of Science by researchers from the University of Basel and the University Hospital Basel, point to new ways to predict, prevent and treat complications of Epstein-Barr virus (EBV) infection.
Read More
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