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Home » Authors » Anette Breindl

Articles by Anette Breindl

Lymph nodes

In times of need, fat cells take on immune functions

May 4, 2022
By Anette Breindl
Fat cells surrounding the lymph nodes could switch jobs in response to a distant infection, taking on immune cell functions, researchers at Johns Hopkins University reported in the May 3, 2022, online issue of Cell Metabolism.
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Inflammation illustration

Innate immune memory underlies inflammatory comorbidities: study

May 2, 2022
By Anette Breindl
Researchers at the University of Pennsylvania have gained new insight into how different inflammatory conditions reinforce each other via trained innate immunity.
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Multiple sclerosis

Study finds targets of T-cell response in multiple sclerosis

April 28, 2022
By Anette Breindl
Screening a panel of potential autoantigens, investigators at the Karolinska Institute have identified four autoantigens that are targeted by the T cells of multiple sclerosis patients.
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Antibiotic resistant bacteria inside a biofilm

ECCMID 2022: In antibiotic development, scientific ingenuity meets a dysfunctional marketplace

April 26, 2022
By Anette Breindl
Antibiotics drugs discovery, Ursula Theuretzbacher told the audience at the 2022 European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), has more than one challenge to overcome.
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Human anatomy

Sex disparities of lupus recapitulated in mouse model

April 25, 2022
By Anette Breindl
A new animal model of systemic lupus erythematosus (lupus) could be useful for understanding the disparity of the disorder, which is vastly more common in women than men.
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Stroke illustration: brain, artery, neurons

Astrocyte-produced enzyme affects neuronal activity, stroke outcomes

April 21, 2022
By Anette Breindl
By altering the balance between neuronal excitation and inhibition, researchers have reduced cell death and improved outcomes in animal models of stroke.
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CAR T cell attacking cancer cells

Testing viruses, vaccines, to increase solid tumor CAR T persistence

April 20, 2022
By Anette Breindl
Solid tumors have been a tougher nut to crack for CAR T cells than B-cell cancers, for two main reasons. Solid tumors have an inhibitors microenvironment that has made it difficult to get durable responses. And identifying antigens as specific as the B-cell markers CD19 and CD22 has been challenging, leading to problems with on-target, off-tumor toxicity.
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3D head brain cancer

AACR 2022: Understanding cancer’s brain is new microenvironment frontier

April 14, 2022
By Anette Breindl
The tumor microenvironment is critical for the ability of cancers to survive and grow, and some aspects of the microenvironment are studied, and targeted, accordingly. Tumor immunology is one of the most active areas of cancer research and has become a pillar of treatment. Others, not so much. “The nervous system is the last component of the microenvironment that people have left completely unrecognized,” Humsa Venkatesh told BioWorld. Even in brain tumors and metastases, where the presence of neurons is glaringly obvious, there has been little attention to how the two interact until recently.
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Digital cancer cells illustration

AACR 2022: Viruses, vaccines, ventricular delivery help solid tumor CAR Ts

April 13, 2022
By Anette Breindl
“We’re still a far cry from reproducible, durable benefits” with CAR T cells targeting solid tumors, Crystal Mackall told the audience at the 2022 annual meeting of the American Association for Cancer Research (AACR). But “we’re beginning to see some signals.” Mackall is the founding director of the Stanford Center for Cancer Cell Therapy.
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AACR 2022

With ADCs established, branching out to irregular conjugation

April 11, 2022
By Anette Breindl
With 11 approved therapeutics in a diversity of targets and indications, antibody-drug conjugates (ADCs) have proved their clinical mettle. But they have not yet reached their full clinical potential, which, in the opinion of Astrazeneca plc’s Kenneth Thress, could transform patient care. The strength of ADCs, he told the audience at an educational session at the 2022 annual meeting of the American Association for Cancer Research (AACR 2022), is that it can turn anything into a targeted therapy.
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