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Home » Authors » Anette Breindl

Articles by Anette Breindl

P53 tumor suppressor

All is loss for P53 mutations, study argues

Sep. 1, 2021
By Anette Breindl
More than half of cancers have mutations in the transcription factor p53, making p53 one of the most frequently mutated genes in solid tumors.
Read More
Single strand RNA

New delivery system SENDs therapeutic RNA without triggering immune system

Aug. 27, 2021
By Anette Breindl
Investigators at MIT have identified a protein capable of delivering its own mRNA to cells, and engineered that protein to deliver mRNA sequences of their choosing. In a mouse model, the team used their approach to deliver the mRNA for two different proteins.
Read More
Elderly hands holding broken brain structure

Study casts dementia subtype as lysosomal storage disorder

Aug. 26, 2021
By Anette Breindl
Researchers from Denali Therapeutics Inc. have identified new functional links between progranulin, lysosomal function, and a subtype of frontotemporal dementia caused by progranulin deficiency (FTD-GRN) that suggest progranulin-mediated FTD could be conceptualized as a lysosomal storage disorder (LSD). They also showed that delivery of their experimental therapeutic PTV:PGRN, also known as DNL-593, reduced cell damage and symptoms of FTD in cell and animal models.
Read More
Petri dish and capsules

Moving side chains amps up peptides' infection-fighting abilities

Aug. 25, 2021
By Subhasree Nag and Anette Breindl
A team of researchers has created peptide-like molecules – "peptoids" – with antiviral properties that could circumvent the naturally occurring antimicrobial peptides' shortcomings.
Read More
Brain and DNA

Gene therapy ameliorates androgen receptor-driven neuromuscular disease

Aug. 24, 2021
By Anette Breindl
For most people, neither polyglutamine disorders nor neuromuscular disorders are likely to be among the things they associate with androgen receptor (AR) dysfunction. But the three are indeed linked. And researchers have reported new insights into the nature of those links that could lead to a treatment for spinal and bulbar muscular atrophy, and possibly other disorders linked to AR signaling dysfunction.
Read More
Single strand RNA

New delivery system SENDs therapeutic RNA without triggering immune system

Aug. 24, 2021
By Anette Breindl
Investigators at MIT have identified a protein capable of delivering its own mRNA to cells, and engineered that protein to deliver mRNA sequences of their choosing.
Read More
Brain and DNA

Gene therapy ameliorates androgen receptor-driven neuromuscular disease

Aug. 20, 2021
By Anette Breindl
For most people, neither polyglutamine disorders nor neuromuscular disorders are likely to be among the things they associate with androgen receptor (AR) dysfunction. But the three are indeed linked. And researchers have reported new insights into the nature of those links that could lead to a treatment for spinal and bulbar muscular atrophy, and possibly other disorders linked to AR signaling dysfunction.
Read More
Long COVID word cloud

‘Not just the flu’ holds for SARS-CoV-2 long-term effects, too

Aug. 19, 2021
By Anette Breindl
When SARS-CoV-2 first emerged in 2020, with respiratory symptoms as the most obvious feature of infection, the most obvious comparison was to influenza. COVID-19, of course, was never just another flu.
Read More
Silhouette of head, brain

Stress hormones affect brain plasticity via distinct mechanisms

Aug. 18, 2021
By Anette Breindl
Researchers have shown that glucocorticoids, a type of steroid hormones, target both neuroplasticity-related genes and genes related to ciliary function in the brain. However, the effects on the different processes are mediated via different receptors, and in response to different stimuli. A study investigated the specific targets of glucocorticoids, giving new insights into the biological mechanisms of stress adaptations, and how they are linked to neural plasticity.
Read More
Silhouette of head, brain

Stress hormones affect brain plasticity via distinct mechanisms

Aug. 10, 2021
By Anette Breindl
Researchers have shown that glucocorticoids, a type of steroid hormones, target both neuroplasticity-related genes and genes related to ciliary function in the brain. However, the effects on the different processes are mediated via different receptors, and in response to different stimuli. A study investigated the specific targets of glucocorticoids, giving new insights into the biological mechanisms of stress adaptations, and how they are linked to neural plasticity.
Read More
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