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Home » Authors » Anette Breindl

Articles by Anette Breindl

VEXAS illustration

ASHG 2020: New inflammatory disease, and maybe, a new classification system

Oct. 29, 2020
By Anette Breindl
Anthony Wynshaw-Boris, professor and chair of the department of genetics and genome sciences at Case Western Reserve University School of Medicine, set a positive tone in his opening talk at the 2020 annual meeting of the American Society of Human Genetics (ASHG). "This is guaranteed to be the best-ever virtual ASHG annual meeting," he told the audience. The opening plenary abstract session, for one, did not disappoint. It began with the definition of a new disease, identified through a new approach, and possibly leading to a new way to think about rheumatic diseases.
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Drug research
ASHG 2020

Many genes with weak effects are key to drug response, too

Oct. 29, 2020
By Anette Breindl
CYBERSPACE – “We are not very good at predicting drug response in the clinic,” Ayesha Muhammad told the audience at the 2020 annual meeting of the American Society of Human Genetics (ASHG), “though it is not for lack of trying.” Nevertheless, adverse drug reactions are among the top 10 causes of in-hospital mortality.
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CRISPR illustration
Bench Press

CRISPR sheds LICHT on brain development…

Oct. 29, 2020
By Anette Breindl
BioWorld looks at translational medicine.
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VEXAS illustration

ASHG 2020: New inflammatory disease, and maybe, a new classification system

Oct. 28, 2020
By Anette Breindl
The opening plenary abstract session at the 2020 annual meeting of the American Society of Human Genetics (ASHG) began with the definition of a new disease, identified through a new approach, and possibly leading to a new way to think about rheumatic diseases.
Read More
Test tubes, dropper
Bench Press

Three-for-two method predicts immune response

Oct. 28, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Macrophages metabolically support muscle; Cutting off AML’s metabolic escape route.
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BioWorld MedTech’s Oncology Extra for Oct. 27, 2020

Oct. 27, 2020
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology, including: Study hints cystectomy not the only answer to muscle-invasive bladder cancer; Drugging resistant androgen receptors; ‘Don’t Eat Me’ signal doubles as ‘Don’t Find Me’; New algorithm may aid in oncology drug development.
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Mouse DNA illustration

ENA 2020: Progress in cancer research can come one mouse at a time, study suggests

Oct. 26, 2020
By Anette Breindl
Under the right circumstances, a single mouse can be as good as a group of eight or 10 animals in predicting whether a tumor will respond to a drug, researchers reported at the 2020 EORTC-NCI-AACR (ENA) Molecular Targets meeting on Saturday. The single-animal approach “allows incorporation of more tumor models within the same resource constraints,” Peter Houghton told reporters at a press conference previewing ENA highlights.
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KRAS protein

KRAS G12C: Adagrasib holds its own at ENA 2020

Oct. 26, 2020
By Anette Breindl
Mirati Therapeutics Inc.’s update on the phase I/II Krystal trial of the KRAS-G12C-targeting adagrasib (MRTX-849) was arguably the most eagerly awaited news, and certainly the most eagerly awaited KRAS-targeting news, to come out of the 2020 EORTC-NCI-AACR (ENA) Molecular Targets meeting. KRAS is one of the most frequently mutated oncogenes across a wide swath of solid tumors, and has been one of the toughest nuts to crack as far as druggability is concerned.
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Microscope
Bench Press

‘Don’t Eat Me’ signal doubles as ‘Don’t Find Me’

Oct. 23, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Prenatal treatment normalizes brain development in Down syndrome model.
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Prostate cancer cells
Bench Press

Drugging resistant androgen receptors

Oct. 22, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Engineered opsin restores vision.
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