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Home » Authors » Anette Breindl

Articles by Anette Breindl

Liver organoid
Multiple drugs, single model

Organoids enable due DILIgence on liver toxicity

Sep. 9, 2020
By Anette Breindl
According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), drug-induced liver injury (DILI) is the leading cause of acute liver failure in the U.S. It is also a leading cause of drug failure in clinical trials. Now, researchers have used liver organoids to develop a polygenic risk score that could predict the risk of liver toxicity for multiple different drugs, regardless of the underlying mechanism.
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BioWorld MedTech’s Oncology Extra for Sept. 8, 2020

Sep. 8, 2020
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology, including: Algorithm improves prediction of hepatocellular carcinoma following hepatitis-driven cirrhosis; MTOR-targeting metabolite discovered; Dartmouth’s Thayer School wins NIH grant.
Read More
Bench Press

Room for improvement in T-cell repertoire profiling

Sep. 8, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Oxygen grows tumors but shrinks metastasis chances; Prion protein’s positive point.
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Gene editing illustration
Bench Press

CRISPR immune suppression strengthens CRISPR gene therapy

Sep. 4, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: MTOR-targeting metabolite discovered; AKG for A-OK aging; Benzodiazepine and barbiturate binding to GABA-A; Giving misfolded proteins a second chance; Agrin-culture grows cartilage; SCAD vs. plaques in heart attacks.
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CAR T cell attacking cancer cells
Painting a bulls-eye

Oncolytic virus, CAR T boost each other in solid tumor treatment

Sep. 3, 2020
By Anette Breindl
Researchers at City of Hope have used a combination of oncolytic virus and CD19-targeting CAR T cells to first force expression of CD19 on tumor cells and then hunt down those cells, eradicating tumors in immunocompetent mouse models and endowing them with immunity to later re-administration of tumor cells.
Read More
Bench Press

Blood studies identify new trait-related variants

Sep. 3, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Teaching T cells restraint.
Read More

BioWorld MedTech’s Oncology Extra for Sept. 1, 2020

Sep. 1, 2020
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology, including: Denoising algorithm may boost signal-to-noise ratios in prostate MRI; Cross-reactive immunity helps antitumor response; iBET you I can kill those metastases; Transatlantic assault on cancer announced.
Read More
Galanin in the brainstem
Bench Press

How running away from your problems works

Aug. 31, 2020
By Anette Breindl
BioWorld looks at translational medicine: Researchers at Emory University have gained new insights into how exercise confers stress resilience.
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Vaccination
Vaccine durability

Thanks for the memories, but could you make them less selective?

Aug. 28, 2020
By Anette Breindl
With COVID-19, questions about how infections cause lasting immunity, or don’t, and how you know and what it all means for vaccines have become a matter of public focus. But some immunologists have been pondering those questions for years. “The immune system has a very good memory,” Bali Pulendran told BioWorld. “Clearly, some viruses and some pathogens can enter the body and stimulate the immune system, and the immune system can remember that encounter for decades.”
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BioWorld MedTech’s Diagnostics Extra for Aug. 27, 2020

Aug. 27, 2020
By Meg Bryant and Anette Breindl
Keeping you up to date on recent developments in diagnostics, including: A.I. tool promises faster, more accurate Alzheimer's diagnosis; Bioluminescent tool tracks DNA break repair; Mechanisms of retinopathy come into focus.
Read More
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