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Home » Authors » Brian Orelli

Articles by Brian Orelli

Cancer cell, dropper, test tubes
AACR 2020

New drugs on the horizon highlighted at AACR

April 28, 2020
By Brian Orelli
CYBERSPACE – At a series of new drugs on the horizon sessions at the 2020 American Association for Cancer Research (AACR) Virtual Annual Meeting I, a variety of companies presented preclinical and clinical data for promising early stage oncology products.
Read More
Antibodies
1+1=5

After a slow start, bispecific antibody space takes off

April 27, 2020
By Brian Orelli
Blincyto (blinatumomab, Amgen Inc.), the first FDA-approved bispecific antibody, gained regulatory approval in 2014, but the intervening years have been fairly bleak for bispecific antibodies as companies worked through technical challenges.
Read More
Telehealth illustration
COVID-19

Amid pandemic, companies scramble to salvage trials, move virtual

April 14, 2020
By Brian Orelli
In order to redirect health care resources and protect patients during the COVID-19 pandemic, many drug companies have paused enrollment in some or all of their ongoing clinical trials.
Read More
Telehealth illustration
COVID-19

Amid pandemic, companies scramble to salvage trials, move virtual

April 13, 2020
By Brian Orelli
In order to redirect health care resources and protect patients during the COVID-19 pandemic, many drug companies have paused enrollment in some or all of their ongoing clinical trials. But patients still in the studies need to be followed for safety and efficacy, creating challenges for the industry.
Read More

Menlo's serlopitant whiffs in two phase III studies

April 6, 2020
By Brian Orelli
Menlo Therapeutics Inc. announced a double dose of bad news with negative results for two phase III trials testing its NK1 receptor antagonist, serlopitant, as a treatment for pruritus (itch) associated with prurigo nodularis, a skin disease characterized by hard, itchy nodules.
Read More
Head filled with digital data
'It's really not going to scale'

Companies face challenges with increasing clinical trial data sources

March 24, 2020
By Brian Orelli
A survey of 149 companies by Tufts Center for the Study of Drug Development found more than two-thirds of clinical trial sponsors were using or piloting at least four different data sources in their clinical trials.
Read More
Biocom panel
Biocom Global Life Sciences Partnering Conference

Pharmas share their needs, wants and offer some advice

March 2, 2020
By Brian Orelli
SAN DIEGO – At the Biocom 10th Annual Global Life Sciences Partnering Conference, panels of pharma executives highlighted what they're looking for to supplement their pipelines and offered advice that ran the gamut from company formation to the courting process to strategies for partnering pipeline drugs and platforms.
Read More
John Hood at the Biocom Global Life Sciences
Sometimes it takes an advocate (or four)

Backstory of the FDA lifting its clinical hold and eventual approval of Inrebic

Feb. 28, 2020
By Brian Orelli
SAN DIEGO – At Biocom's 10th Annual Global Life Sciences Partnering Conference, a panel of players intimately familiar with last year's approval of myelofibrosis treatment Inrebic (fedratinib) explained the backstory of how they got the JAK2 kinase inhibitor off an FDA clinical hold, wrangled the rights to the drug back from the big pharma owner that had acquired the drug from Targegen Inc. and eventually helped the drug gain FDA approval after selling the rights to another large company.
Read More
Serving piece of pie chart
Multiple spin-offs in the works

Pharmas break up to accelerate growth

Feb. 11, 2020
By Brian Orelli
Even as the volume of mergers and acquisitions in 2019 reached the highest level in the last 10 years, multiple big pharma companies are looking to get smaller, spinning off units into separate entities.
Read More
Inflammatory/Immune: Filgotinib

Filgotinib looks to JAK up sales with multiple indications

Feb. 10, 2020
By Brian Orelli
Filgotinib (GLPG-0634) has the potential to be a blockbuster drug, according to Cortellis Drugs to Watch analysis, but it may take a few approvals in various indications to reach the coveted mark of $1 billion in annual sales.
Read More
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