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Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

Adenovirus cells
Newco news

Vironexis exits stealth with 10+ AAV-delivered immuno-oncology candidates

Sep. 12, 2024
By Brian Orelli
Vironexis Biotherapeutics Inc. came out of stealth mode today, disclosing that it has more than 10 product candidates it’s been developing over the last three years. The therapies are built on the company’s AAV-based platform, Transjoin, which is designed to have patients' livers express bispecific antibodies that bind to both CD3 on T-cells and various targets on tumor cells.
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Immune

Candid launches with bispecific antibodies and $370M in hand

Sep. 10, 2024
By Brian Orelli
Candid Therapeutics Inc. launched with ex-China control of two bispecific T-cell engager antibodies that it plans to develop for autoimmune diseases. The San Diego-based company will start off with a pocketful of cash, having raised over $370 million for the development of the in-licensed candidates.
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Red rocket launch button on keyboard
Newco news

Candid launches with bispecific antibodies and $370M in hand

Sep. 9, 2024
By Brian Orelli
Candid Therapeutics Inc. launched with ex-China control of two bispecific T-cell engager antibodies that it plans to develop for autoimmune diseases. The San Diego-based company will start off with a pocketful of cash, having raised over $370 million for the development of the in-licensed candidates.
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U.S. flag and White House podium

How US politics could shape the future of biopharma

Aug. 29, 2024
By Brian Orelli
During a webinar arranged by Demy-Colton, panelists discussed a wide range of potential outcomes that might occur depending on which political party ends up in power next year. From tweaks to the Inflation Reduction Act to new laws to the Federal Trade Commission's regulation of M&As, there’s potential for the government to have substantial effects on the drug development industry.
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Dendritic cells
Newco news

Diakonos raises $11.4M for its dendritic cell vaccine

Aug. 27, 2024
By Brian Orelli
Diakonos Oncology Corp. has developed a process to manufacture dendritic cell vaccines that the company believes are substantially more potent than its predecessors.
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Ideaya opening a new market with its first-in-class MAT2A inhibitor

July 8, 2024
By Brian Orelli
Ideaya Biosciences Inc. appears to be in the lead to develop a treatment for tumors with deletions in both copies of methylthioadenosine phosphorylase (MTAP). Despite the large market with an estimated annual incidence rate in the U.S. of approximately 75,000 patients, there are no FDA approved therapies for MTAP-deleted solid tumors.
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mRNA on digital background
Newco news

Exsilio launches with $82M to develop mRNA-based gene therapies

July 2, 2024
By Brian Orelli
Exsilio Therapeutics emerged from stealth mode on June 25, 2024, with $82 million from a series A financing that was co-led by Novartis Venture Fund and Delos Capital. The company plans to use naturally occurring, mobile genetic elements to integrate therapeutic genes at a defined location in the genome, making it safer than random integration, which can cause tumor formation.
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Blue injector pens

No longer a two-horse race: Obesity drug competition expands

June 27, 2024
By Brian Orelli
The obesity market is hot with Novo Nordisk A/S generating $6.3 billion in sales from its semaglutide-containing drugs, Ozempic, Saxenda, Rybelsus and Wegovy, in the first quarter of 2024 and Eli Lilly and Co. bringing in $2.3 billion for its tirzepatide-containing drugs, Zepbound and Mounjaro, in the same quarter. It appears unlikely the market will be a two-horse race for much longer though.
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mRNA on digital background
Newco news

Exsilio launches with $82M to develop mRNA-based gene therapies

June 25, 2024
By Brian Orelli
Exsilio Therapeutics emerged from stealth mode on June 25, 2024, with $82 million from a series A financing that was co-led by Novartis Venture Fund and Delos Capital. The company plans to use naturally occurring, mobile genetic elements to integrate therapeutic genes at a defined location in the genome, making it safer than random integration, which can cause tumor formation.
Read More
AI-generated illustration of heart and metabolic impact

Marea launches with $190M to tackle cardiometabolic diseases

June 18, 2024
By Brian Orelli
Marea Therapeutics came out of stealth mode on June 18, after raising a combined $190 million through its series A and B financings. The series A round was led by Third Rock Ventures, and the series B round was led by Sofinnova Investments and co-led by Forbion, Perceptive Xontogeny Venture Fund and Venbio.
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