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Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

Coronavirus vaccine/therapeutics illustration

Getting cellular with COVID-19 adaptive immunity

Aug. 10, 2020
By Brian Orelli
Much of the research on the immune response in patients with COVID-19 has focused on the humoral antibody response.
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Brain illustration

Sangamo snags Novartis with a $795M neurodevelopmental deal

July 31, 2020
By Brian Orelli
Sangamo Therapeutics Inc. continued its collaboration spree, signing up its sixth big pharma/biotech partner: Novartis AG. The three-target deal will use Sangamo's zinc finger protein transcription factors to up-regulate undisclosed genes to treat autism spectrum disorder and other neurodevelopmental disorders.
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Health professional pointing stethoscope at Clinical Trial words, icons

Getting more efficient with clinical trials

July 20, 2020
By Brian Orelli
The number of clinical trials initiated each year has continued to grow every year over the last decade, sans a slight decrease in 2013, according to data presented in a webcast facilitated by Applied Clinical Trials.
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Geoffrey von Maltzahn, co-founder and CEO, Tessera Therapeutics
Biotech's worst kept secret comes out of stealth mode

From gene editing to gene writing

July 13, 2020
By Brian Orelli
In case you haven't heard, Tessera Therapeutics Inc. is working on techniques to write genes into the genome of patients. Tessera, which was developed in Flagship Pioneering Inc.'s Flagship Labs and became a stand-alone incorporated company two years ago, recently came out of stealth mode to highlight its Gene Writing platform based on mobile genetic elements, such as transposons and retrotransposons.
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IV insertion
AACR Virtual Meeting II

COVID-19 and cancer

June 29, 2020
By Brian Orelli
Multiple sessions at the American Association for Cancer Research Virtual Annual Meeting II covered how COVID-19 is affecting cancer patients, from how clinical trials needed to be modified during the pandemic to how real-world evidence can play a role now and in the future.
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FDA icons
AACR Virtual Meeting II

FDA doles out advice to cancer companies

June 25, 2020
By Brian Orelli
At a session of the American Association for Cancer Research Virtual Annual Meeting II, multiple FDA regulators gave presentations on various topics to help drug companies understand the ever-evolving oncology regulation.
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AACR Virtual Meeting II

Resistance to targeted therapies: It works until it doesn't

June 24, 2020
By Brian Orelli
Targeted therapy offers an opportunity for personalized medicine that's specific for a patient's tumor, but the hyper-focused treatment creates possibilities for cells to mutate and become resistant to the therapy.
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Connected drug capsules
AACR Virtual Meeting II

Combination therapies: Searching for synergy

June 23, 2020
By Brian Orelli
Almost all solid tumors are treated with multiple drugs because the combinations have better efficacy than single-agent treatments. But finding those combinations can be difficult in an ever-growing sea of pair-wise combinations.
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AACR Virtual Meeting II

Taking immunotherapy to the next level

June 23, 2020
By Brian Orelli
Bolstered by the success of CTLA4 and PD-(L)1 antibodies, companies are exploring new targets to encourage the immune system to attack tumors. "While these agents have demonstrated efficacy in a proportion of cancer patients, there clearly is room for improvement to lift the tail of the curve," Michele Teng, associate professor at the QIMR Berghofer Medical Research Institute, told the audience at the clinical trials plenary session of the American Association for Cancer Research Virtual Annual Meeting II, where researchers presented data from a pair of immunotherapies looking to build on the success targeting PD-(L)1.
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MBC Biolabs
Worth a lot more than a tour of a candy manufacturing plant

Drug developers' Golden Ticket

June 16, 2020
By Brian Orelli
It won't get you the right to see the Oompa Loompas, but a Golden Ticket for MBC Biolabs could be even more valuable to a startup.
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View All Articles by Brian Orelli

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