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BioWorld - Wednesday, July 9, 2025
Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

Geoffrey von Maltzahn, co-founder and CEO, Tessera Therapeutics
Biotech's worst kept secret comes out of stealth mode

From gene editing to gene writing

July 13, 2020
By Brian Orelli
In case you haven't heard, Tessera Therapeutics Inc. is working on techniques to write genes into the genome of patients. Tessera, which was developed in Flagship Pioneering Inc.'s Flagship Labs and became a stand-alone incorporated company two years ago, recently came out of stealth mode to highlight its Gene Writing platform based on mobile genetic elements, such as transposons and retrotransposons.
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IV insertion
AACR Virtual Meeting II

COVID-19 and cancer

June 29, 2020
By Brian Orelli
Multiple sessions at the American Association for Cancer Research Virtual Annual Meeting II covered how COVID-19 is affecting cancer patients, from how clinical trials needed to be modified during the pandemic to how real-world evidence can play a role now and in the future.
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FDA icons
AACR Virtual Meeting II

FDA doles out advice to cancer companies

June 25, 2020
By Brian Orelli
At a session of the American Association for Cancer Research Virtual Annual Meeting II, multiple FDA regulators gave presentations on various topics to help drug companies understand the ever-evolving oncology regulation.
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AACR Virtual Meeting II

Resistance to targeted therapies: It works until it doesn't

June 24, 2020
By Brian Orelli
Targeted therapy offers an opportunity for personalized medicine that's specific for a patient's tumor, but the hyper-focused treatment creates possibilities for cells to mutate and become resistant to the therapy.
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Connected drug capsules
AACR Virtual Meeting II

Combination therapies: Searching for synergy

June 23, 2020
By Brian Orelli
Almost all solid tumors are treated with multiple drugs because the combinations have better efficacy than single-agent treatments. But finding those combinations can be difficult in an ever-growing sea of pair-wise combinations.
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AACR Virtual Meeting II

Taking immunotherapy to the next level

June 23, 2020
By Brian Orelli
Bolstered by the success of CTLA4 and PD-(L)1 antibodies, companies are exploring new targets to encourage the immune system to attack tumors. "While these agents have demonstrated efficacy in a proportion of cancer patients, there clearly is room for improvement to lift the tail of the curve," Michele Teng, associate professor at the QIMR Berghofer Medical Research Institute, told the audience at the clinical trials plenary session of the American Association for Cancer Research Virtual Annual Meeting II, where researchers presented data from a pair of immunotherapies looking to build on the success targeting PD-(L)1.
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MBC Biolabs
Worth a lot more than a tour of a candy manufacturing plant

Drug developers' Golden Ticket

June 16, 2020
By Brian Orelli
It won't get you the right to see the Oompa Loompas, but a Golden Ticket for MBC Biolabs could be even more valuable to a startup.
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Hand holding IPO, financial icons

IPOing in a pandemic: How to raise $100M+ from your spare bedroom

May 26, 2020
By Brian Orelli
The pandemic hasn't kept biotechs from going public. In fact, through the first five or so months of the year, the industry has raised more than $3.3 billion through IPOs, more capital than biotechs have raised during the first five months of any of the previous 20 years.
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Doctor and patient consultation

Clinical trials still lack diversity, FDA encouraging inclusiveness

May 18, 2020
By Brian Orelli
Women, black and Hispanic/Latinx participants were underrepresented in pivotal clinical trials for drugs approved from 2007 to 2017, according to a new report by the Tufts Center for the Study of Drug Development. In the pivotal clinical trials, 44.9% of patients were women. Participants who identified as black or of African descent were the most underrepresented participant group, representing 5.4% of participants in clinical trials.
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Leukemia illustration
The umbralisib and ublituximab band

TG Therapeutics sings U2 interim success in CLL

May 5, 2020
By Brian Orelli
TG Therapeutics Inc. got a dose of good news when the independent data safety monitoring board recommended that the UNITY-CLL study be stopped early for superior efficacy after an interim analysis showed its umbralisib and ublituximab combination (U2) helped patients with chronic lymphocytic leukemia (CLL).
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