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BioWorld - Sunday, May 11, 2025
Home » Authors » John Fox

John Fox

Articles

ARTICLES

Research lab illustration

Glycosylation study casts new light on health and disease

Feb. 10, 2021
By John Fox
Australian researchers at the Walter and Eliza Hall Institute of Medical Research in Melbourne have developed new yeast- and antibody-based methods to determine how tryptophan C-mannosylation, an unusual protein glycosylation modification, impacts the stability and function of disease-relevant proteins.
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Hands holding petri dish

New dengue virus inhibitor shows preclinical promise

Feb. 4, 2021
By John Fox
A Singapore study led by the Novartis Institute for Tropical Diseases (NITD) has shown that a novel small-molecule inhibitor of the dengue virus (DENV) nonstructural protein 4B (NS4B) has favorable pharmacokinetics and efficacy in preclinical animal models, the authors reported in the February 3, 2021, edition of Science Translational Medicine.
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Cardiovascular.png

PERK inhibition promising for pulmonary arterial hypertension

Feb. 1, 2021
By John Fox
The first selective inhibitor of protein kinase R- (PKR)-like endoplasmic reticulum kinase (PERK), GSK-2606414, has been shown to attenuate vascular remodeling in pulmonary arterial hypertension (PAH) in mice, according to a study reported in the January 26, 2021, edition of Science Signaling.
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Brain-DNA illustration

Astrocytic ApoE mediates memory consolidation in mice

Jan. 28, 2021
By John Fox
A study led by scientists at the University of Science and Technology of China in Hefei City is the first to show that astrocytic apolipoprotein E (ApoE) regulates neuronal epigenetic states via reprogramming lipid metabolism, which was shown to control brain function, in particular memory consolidation, in mice.
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Lungs

Microbial tyrosine metabolism protects against asthma

Jan. 27, 2021
By John Fox
An Australian-led study reported in the January 25, 2021, online edition of Nature Immunology has identified a new immunomodulatory pathway within the gut-lung axis that enhances microbial tyrosine metabolism, which could be targeted to treat or prevent atopic asthma and other inflammatory diseases.
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Mammogram

AR agonist-based strategy proposed for ER+ breast cancer

Jan. 26, 2021
By John Fox
An international study led by Australian scientists has shown for the first time that the androgen receptor (AR) is a tumor suppressor in estrogen receptor-positive (ER+) metastatic breast cancer, including in endocrine therapy resistance, which supports the use of an AR agonist-based treatment strategy.
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Optogenetics illustration

HELP is on its way for herpetic stromal keratitis

Jan. 19, 2021
By John Fox
Transient gene editing of the herpes simplex virus type 1 using mRNA-based CRISPR was shown for the first time to be effective against herpetic stromal keratitis in mice and blocked HSV-1 replication in human corneas, Chinese researchers reported in the January 11, 2021, online edition of Nature Biotechnology.
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Hands holding petri dish

Antibody protects broadly against flaviviruses, without ADE

Jan. 12, 2021
By John Fox
A study led by Australian researchers at the University of Queensland has shown that a newly developed antibody targets the flavivirus nonstructural protein 1 and was shown to reduce viremia and improve survival in mouse models of dengue, Zika and West Nile infections.
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Antibody

Antibodies target fibrotic and autoimmune diseases

Jan. 11, 2021
By John Fox
A Sino-U.S. study has shown that the increased expression of the small secreted glycoprotein follistatin-like 1 is critical in the pathogenesis of multiple fibrotic and systemic autoimmune diseases, the authors reported in the January 6, 2021, print edition of Molecular Therapy after earlier publication online.
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Stomach and intestine

B-cell transcription factor helps gut regenerate

Jan. 4, 2021
By John Fox
A Chinese study has shown that the recently discovered transcription factor Bach2, which is important in B-cell development and progression of inflammatory disease, also regulates gastrointestinal regeneration by facilitating DNA repair after ionizing radiation exposure.
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View All Articles by John Fox

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