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Home » Authors » John Fox

John Fox

Articles

ARTICLES

Blood cells and bacteria

Antimicrobial polymers AMP up fight against MDR bacteria

Dec. 1, 2020
By John Fox
An international study led by Nanyang Technological University in Singapore has designed and synthesized broad-spectrum antimicrobial polymers (AMPs) and demonstrated the safety and efficacy of two such agents against multidrug-resistant (MDR) bacteria in mouse models of sepsis.
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Blood cells and bacteria

Antimicrobial polymers AMP up fight against MDR bacteria

Nov. 25, 2020
By John Fox
An international study led by Nanyang Technological University in Singapore has designed and synthesized broad-spectrum antimicrobial polymers (AMPs) and demonstrated the safety and efficacy of two such agents against multidrug-resistant (MDR) bacteria in mouse models of sepsis.
Read More
Enterobacteriaceae

Neuro-drug repurposed to treat MDR gram-negative sepsis

Nov. 19, 2020
By John Fox
A study by Australian microbiologists at Queensland, Melbourne and Griffiths universities has shown that the candidate neurodegenerative disease drug PBT-2, combined with a polymyxin antibiotic, induced potent antimicrobial activity against polymyxin-resistant gram-negative pathogens.
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Brain cancer illustration

Ependymomas may respond to PARP inhibitors

Nov. 17, 2020
By John Fox
Chinese scientists have been the first to show that combining anti-cancer poly [ADP-ribose] polymerase (PARP) inhibitors with radiotherapy may be effective for treating ependymoma CNS tumors expressing elevated levels of the protein chromosome X open reading frame 67 (CXorf67).
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Mammogram

Metabolic pathway-based TNBC subtyping reveals potential new targets

Nov. 12, 2020
By John Fox
A Chinese multi-omics analysis of the largest triple-negative breast cancer (TNBC) database compiled to date has identified three new distinct TNBC metabolic-pathway-based subtypes (MPSs), which could be targeted therapeutically.
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KRAS protein

Study shows how mutant KRAS initiates pancreatic cancer

Nov. 10, 2020
By John Fox
Single-cell genomic analysis has shown that mutations in the KRAS oncogene co-opt a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells, initiating pancreatic ductal adenocarcinoma, Chinese researchers reported in the November 3, 2020, edition of Nature Cancer.
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Cancer cell

Organoids enable tumor genotype-phenotype mapping

Nov. 9, 2020
By John Fox
Japanese researchers have developed a new organoid biobank with which to identify molecular subtypes of rare gastroentero-pancreatic neuroendocrine neoplasms using genotype-phenotype mapping, they reported in the November 6, 2020, online edition of Cell.
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Brain and DNA

Study links two ALS mechanisms

Nov. 2, 2020
By John Fox
Mutations in the annexin A11 gene contribute to motor neuron degeneration in amyotrophic lateral sclerosis by disrupting cellular calcium ion homeostasis and stress granule protein disassembly contributing to ALS neurodegeneration.
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Brain waves

New tool probes neurodevelopmental disorder genes

Oct. 29, 2020
By John Fox
Australian geneticists have developed a new tool, the Single Nucleotide Association Test for CNVs, with which to analyze copy number variations and their associations in genetic neurodevelopmental disorders.
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Lungs

Protecting telomeres prevents lung fibrosis

Oct. 21, 2020
By John Fox
A collaborative Sino-Australian study led by scientists at the Institute of Ageing Research at Hangzhou Normal University in Chongqing has identified a new target for enhancing respiratory function and preventing stress-induced premature lung aging and fibrosis due to environmental stresses in mice.
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View All Articles by John Fox

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