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Home » Authors » John Fox

John Fox

Articles

ARTICLES

Gloved hand holding petri dish in lab

Zika-specific therapy found to protect fetal mouse brains

Nov. 11, 2021
By John Fox
A Chinese study led by scientists at Nanjing University is the first to show that modified small extracellular vesicles can cross the placenta and blood-brain barrier to target drug delivery in mice infected with the Zika virus, in which they were shown to significantly reduce fetal neurological damage, including microcephaly.
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Antibody-drug conjugate

Antibody discovery platform increases cancer immunotherapy targets

Nov. 8, 2021
By John Fox
An international study led by U.S. oncologists at Children's Hospital of Philadelphia has successfully used a new antibody discovery platform developed by Myrio Therapeutics of Melbourne, Australia, to help identify and target key drivers of neuroblastoma in mouse models, the authors reported in the November 3, 2021, issue of Nature.
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Pills and bottle

New treatment targets identified in opiate abstinence

Nov. 3, 2021
By John Fox

A study led by researchers at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, has shown that amygdala kappa-opioid receptor-dependent upregulation of glutamate transporter 1 mediates depressive-like behaviors in mouse models of opiate abstinence.


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Petri dish and capsules

Chemoattractant attachment boosts antibiotic efficacy

Oct. 28, 2021
By John Fox

Attaching a modified bacterial-derived formyl peptide chemoattractant to an antibiotic enhanced recruitment of neutrophils and improved their bactericidal ability in mouse models, according to a study led by European Molecular Biology Laboratory Australia researchers at Monash University in Melbourne.


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Stomach and esophagus

Study casts light on DNA damage in esophageal cancer

Oct. 27, 2021
By John Fox
The Cancer Grand Challenges Mutographs study, a combined genetic and epidemiological analysis of data from eight countries with widely different incidences of esophageal squamous cell carcinomas (ESCC), has unexpectedly failed to identify mutational signatures indicating DNA damage that could account for global ESCC incidence variations.
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Pain illustration

New spondyloarthritis therapeutic target identified

Oct. 21, 2021
By John Fox
The proinflammatory cytokine macrophage migration inhibitory factor has been demonstrated to drive the induction and progression of spondyloarthritis in mice and to be associated with human disease, according to the findings of an international study led by researchers at the University of Toronto in Ontario, Canada.
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Coronavirus mutation illustration

New vaccine targets multiple coronaviruses in mice

Oct. 19, 2021
By John Fox
A new engineered glycated vaccine induced production of neutralizing antibodies against severe acute respiratory coronavirus 2 (SARS-CoV-2) and other coronaviruses in mice, scientists at The University of Osaka and the RIKEN Center for Integrative Medical Science in Yokohama have reported.
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Cancer cell, dropper, test tubes

PDAC priming boosts chemotherapeutic efficacy

Oct. 18, 2021
By John Fox
Pretreatment with an experimental focal adhesion kinase inhibitor has been shown to improve chemotherapeutic efficiency and reduce metastasis in preclinical mouse and patient-derived models of pancreatic ductal adenocarcinoma (PDAC), with this priming regimen soon to enter phase II trials for PDAC using a novel, clinically relevant FAK inhibitor.
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Lung cancer illustration

Overcoming EGFR-targeted TKI lung cancer resistance

Oct. 14, 2021
By John Fox
A novel pharmacologically targetable metabolic mechanism driving resistance to epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitors (TKIs) has been identified in preclinical models of lung cancer in a Chinese study led by scientists at Shanghai Jiao Tong University School of Medicine.
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Bacteria in petri dishes

Potent selective pan-serotype dengue inhibitor developed

Oct. 13, 2021
By John Fox
Blocking the interaction between two dengue virus (DENV) nonstructural proteins, NS3 and NS4B, with a newly developed small-molecule inhibitor resulted in potent antiviral activity in mouse models, according to an international collaborative study led by scientists at the University of Leuven (KU Leuven), CD3 the Centre for Drug Design and Discovery in Leuven, and Janssen Pharmaceutica in Beerse, Belgium.
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