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Home » Authors » John Fox

John Fox

Articles

ARTICLES

Amyloid plaque on nerve cell

Gene signature governs anti-plaque microglia in AD

May 28, 2021
By John Fox
Single-cell gene studies at Duke-NUS Medical School in Singapore and Monash University in Melbourne, Australia, have shown that gene expression signatures underlie the microglial phagocytosis of beta-amyloid (Abeta) plaque in patients with Alzheimer's disease (AD), the authors reported in the May 20, 2021, edition of Nature Communications.
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Hepatitis C virus

Study casts new light on chronic HCV infection

May 27, 2021
By John Fox
A Japanese study led by researchers at Osaka University has discovered a previously unknown molecular mechanism by which the hepatitis C virus (HCV) interacts with the human immune system to cause chronic liver infection.
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Stem cells

"Invisible" T cells bioengineered from human iPSCs

May 25, 2021
By John Fox
Japanese scientists led by Shin Kaneko, an associate professor in the Center for iPS Cell Research and Application at Kyoto University, have developed the first practical bioengineering strategy for generating a universal pluripotent stem cell.
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Gloved hand holding petri dish in lab

Study identifies colistin resistance drug target

May 20, 2021
By John Fox
A Chinese study led by scientists at Zhejiang University in Hangzhou City has identified a linker of resistance from the mobile colistin resistance gene 3, which might represent a promising drug target against which to develop small-molecule inhibitors to reverse colistin resistance.
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Arthritis pain illustration

T-cell modulation elicits long-term arthritis remission

May 19, 2021
By John Fox
British and Taiwanese scientists have described a novel approach to the treatment of autoimmune rheumatoid arthritis, using an already approved DNA-methylation inhibitor, which was shown to effectively treat active inflammatory disease in animal models.
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Stomach, H. pylori

H. pylori oncoprotein-induced genome instability may underlie gastric cancer

May 14, 2021
By John Fox
A Japanese study has found that the Helicobacter pylori oncoprotein, CagA, elicited transient 'BRCAness', inducing genomic instability via DNA double-strand breaks and defective homologous recombination. The effects may underlie the gastric carcinogenesis associated with chronic H. pylori infection.
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Tau protein in Alzheimer's disease

Study identifies four Alzheimer’s subtypes

May 5, 2021
By John Fox
An international collaborative study led by scientists at Sweden’s Lund University has classified Alzheimer’s disease into four distinct subtypes, which has important implications for the management of the progressive neurodegenerative disease, the authors reported in the April 29, 2021, edition of Nature Medicine.
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Hands holding petri dish

Mitochondrial peptide causes septic shock nosocomials, mortality

May 4, 2021
By John Fox
A Korean/U.S. collaborative study has shown that increased circulating mitochondrial N-formyl peptide contributes to development of secondary hospital-acquired (nosocomial) infections and increased mortality in septic shock patients who survived the early hyperinflammatory phase.
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Stroke illustration: brain, artery, neurons

Cell death finding may improve stroke management

April 28, 2021
By John Fox
Under certain circumstances, a normally innocuous key molecular intermediate of regular cell metabolism, farnesyl pyrophosphate, can trigger neuronal lysis and cell death, according to a study led by Chinese researchers at Tsinghua and Peking universities in Beijing.
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Mosquito

Collaboration promotes new antimalarial drug development

April 27, 2021
By John Fox
A collaboration aimed at identifying and developing potential new antimalarial drug candidate drugs has been announced between Walter and Eliza Hall Institute for Medical Research in Melbourne, Australia, and Janssen Pharmaceutica, with assistance from Johnson & Johnson Innovation.
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View All Articles by John Fox

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