Jack Taunton and colleagues from the University of California, San Francisco have developed salicylaldehyde-based chemical probes that reversibly and covalently modify the catalytic lysine of protein kinases, with sustained occupancy in cells and animals.
In a study reported in the April 27, 2022, online edition of Nature, an international team of researchers has for the first time demonstrated a three-way interaction between neurons, immune cells and plaques as a key component of atherosclerosis.
Researchers led by Doron Merkler from the University of Geneva have shown how post local infection, a fraction of resting CD8+ tissue resident memory cells cross-reacted with antigens of the CNS to become subsequently activated and drive immunopathological responses in the CNS.
A team of scientists led by Liang Ge from Tsinghua University have identified a chaperonin subunit CCT2 as a new type of aggrephagy receptor which specifically accelerates the autophagic clearance of solid aggregates independent of ubiquitination, providing a promising therapeutic target for neurodegenerative diseases.
A multidisciplinary team of scientists has discovered the mechanism that controls synaptic pruning of new neurons in the adult brain. The team discovered that microglial cells control the number of synapses by "eating" excessive synapses.
A team of researchers at Tokyo Metropolitan University have discovered that osmolytes such as mannitol, which are used to treat increased intraocular or intracranial pressure, can cause kidney damage by inducing hyperosmotic stress that leads to epithelial-mesenchymal transition (EMT) of the tubular epithelial cells.
Timothy syndrome, a rare autosomal-dominant disorder, is characterized by presence of a heart arrhythmia (long QT syndrome), which causes the cardiac muscle to take longer than usual to recharge between beats and can result in sudden death. Now scientists at Columbia University have discovered that a common FDA-approved over-the counter cough suppressant, dextromethorphan, can shorten the prolonged QT intervals in both cellular and mouse models of TS.
Researchers have discovered a blood signature of protein isoforms that could potentially predict which patients may reject a new organ transplant, helping inform therapeutic decisions. The findings of this study are reported online in the January 27th edition of Science.
A study by researchers led by David James from the University of Sydney showcases the diversity in metabolic responses observed across different mouse strains exposed to two different diets that demonstrates the heritability of metabolic traits.
In a recent study, investigators led by Tony Tiganis at Monash University, Australia have identified that upregulation of the enzyme NOX4 (NADPH oxidase 4) boosted levels of reactive oxygen species and protected development of insulin resistance in both aged as well as obese mice.
