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Home » Authors » Mar de Miguel

Articles by Mar de Miguel

3D illustration demonstrating inflammation and scarring of the myelin sheath
Neurology/psychiatric

Immunoproteasome triggers neurodegeneration in multiple sclerosis

June 26, 2025
By Mar de Miguel
No Comments
In multiple sclerosis (MS), an alteration of neuronal metabolism caused by dysfunction of its proteasome, the cellular machinery responsible for recycling proteins, contributes to neurodegeneration in this inflammatory disease. This finding could be explored for the development of drugs that protect neurons from damage in MS and other neurodegenerative disorders.
Read More
Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 18, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos.
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 17, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos. These studies aim to address the shortage of immunocompatible organ donors while shedding light on some of the most fundamental questions in developmental biology.
Read More
Model of fecal microbiota transplantation with glowing microbiota flowing between a donor and recipient
Gastrointestinal

Gut microbiome leads to metabolic and immune changes after transplant

June 13, 2025
By Mar de Miguel
No Comments
Is fecal microbiota transplant effective? Is it really safe? And is it really all the same? Scientists at the University of Chicago have investigated the regional differences in gut environments to question these interventions.
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Model of fecal microbiota transplantation with glowing microbiota flowing between a donor and recipient
Gastrointestinal

Gut microbiome leads to metabolic and immune changes after transplant

June 11, 2025
By Mar de Miguel
No Comments
Is fecal microbiota transplant effective? Is it really safe? And is it really all the same? Scientists at the University of Chicago have investigated the regional differences in gut environments to question these interventions to analyze the microbiome differences and their effects after transplantation form different intestine areas. The results show how host-microbe mismatches after these interventions could affect gut health.
Read More
Model of fecal microbiota transplantation with glowing microbiota flowing between a donor and recipient
Gastrointestinal

Gut microbiome leads to metabolic and immune changes after transplant

June 10, 2025
By Mar de Miguel
No Comments
Is fecal microbiota transplant effective? Is it really safe? And is it really all the same? Scientists at the University of Chicago have investigated the regional differences in gut environments to question these interventions to analyze the microbiome differences and their effects after transplantation form different intestine areas. The results show how host-microbe mismatches after these interventions could affect gut health.
Read More
Art concept for decoding DNA
Aging

Epigenetics tells the story of aging blood cells

June 5, 2025
By Mar de Miguel
No Comments
The variety of blood cells decreases with age. Some are lost, while others become dominant, leading to a loss of functional diversity. This, in turn, weakens the immune system in older individuals and increases the risk of developing hematological diseases. Scientists in Barcelona have developed a method based on DNA methylation that works like a barcode. EPI-Clone identifies and traces the origin of blood cells to measure the complexity of these clones in aging humans and mice.
Read More
Cancer cell in the cross-hairs
Cancer

Pan-cancer proteome atlas reveals new biomarkers and targets

June 3, 2025
By Mar de Miguel
No Comments
An international group of scientists has completed the first draft of The Pan-Cancer Proteome Atlas (TPCPA). The project is based on mass spectrometry of 22 cancer types, which has identified more than 9,000 proteins from 1,000 tumors. The results reveal which proteins allow for the classification of different cancer types, biomarkers and potential therapeutic targets, which are now available to the entire scientific community.
Read More
Illustration of mast cell emitting granules
Drug design, drug delivery & technologies

Dual-action synthetic peptides could fight superbugs

June 2, 2025
By Mar de Miguel
No Comments
A peptide with a dual mechanism of action – it dissolves the bacterial membrane and activates the immune system – could be an effective weapon against microorganisms that have evolved ways to evade antibiotics, as superbugs do. Scientists at the University of Pennsylvania (UPenn) have designed stable synthetic peptides that activate mast cell receptors, which are cells involved in the innate and adaptive immune response. This dual approach eliminates bacteria and recruits neutrophils to finish the job.
Read More
Art concept for decoding DNA
Aging

Epigenetics tells the story of aging blood cells

May 28, 2025
By Mar de Miguel
No Comments
The variety of blood cells decreases with age. Some are lost, while others become dominant, leading to a loss of functional diversity. This, in turn, weakens the immune system in older individuals and increases the risk of developing hematological diseases. Scientists in Barcelona have developed a method based on DNA methylation that works like a barcode. EPI-Clone identifies and traces the origin of blood cells to measure the complexity of these clones in aging humans and mice.
Read More
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