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Home » Authors » Xavier Bofill Bruna

Xavier Bofill Bruna

Articles

ARTICLES

3D representation of tumor
Cancer

Inhibition of mutant IDH1 restores solid tumor immune sensitivity

July 18, 2024
By Xavier Bofill Bruna
Mutations in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) induce tumorigenesis due to generation of the oncometabolite (R)-2-hydroxyglutarate (R-2HG). A hallmark of solid tumors carrying mutations in IDH1 is immune evasion by T-cell exclusion and altered epigenetic state. Researchers from the Center for Cancer Research, Massachusetts General Hospital have published a study in Science on July 12, 2024, in which they demonstrate that inhibiting mutant IDH1 restored antitumoral immunity.
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Human body skeleton with DNA science background art

Blueprint’s work behind drug for fibrodysplasia ossificans progressiva

June 5, 2024
By Xavier Bofill Bruna
Fibrodysplasia ossificans progressiva (FOP) is a rare and life-threatening genetic disease caused by gain-of-function mutations in the ALK2 gene, which encodes activin receptor-like kinase 2. Blueprint Medicines Corp. has elucidated the discovery of their ALK2 inhibitor BLU-782, which is now in phase II studies at Ipsen SA for the treatment of FOP.
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Human body skeleton with DNA science background art
Musculoskeletal

Blueprint’s work behind drug for fibrodysplasia ossificans progressiva

June 5, 2024
By Xavier Bofill Bruna
Fibrodysplasia ossificans progressiva is a rare and life-threatening genetic disease caused by gain-of-function mutations in the ALK2 gene, which encodes activin receptor-like kinase 2. Blueprint Medicines Corp. has elucidated the discovery of their ALK2 inhibitor BLU-782, which is now in phase II studies at Ipsen for the treatment of FOP.
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Medical illustration showing layers of a blood vessel
Infection

Ephrin inhibition ameliorates cell dysfunction and symptoms in septic mice

May 8, 2024
By Xavier Bofill Bruna
Sepsis occurs when there is a dysregulated host response to infection, resulting in organ dysfunction. According to the Global Burden of Disease study, about 50 million people annually worldwide develop severe sepsis or septic shock, and 11 million of them die. Growing evidence suggests that changes to the vascular endothelium, which becomes more permeable to fluid, protein and inflammatory cells, are behind the pathogenesis of sepsis and septic shock.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

Researchers find similarities, but also differences, in long COVID subtypes

April 15, 2024
By Xavier Bofill Bruna
In a study from the PHOSP-COVID and ISARIC-4C consortia in the U.K., researchers have discovered inflammatory processes taking place during what is termed “long COVID.” Long COVID is defined by the World Health Organization (WHO) as the continuation or development of new symptoms for 3 or more months after the initial SARS-CoV-2 infection. It is estimated that 1 in 10 SARS-CoV-2 infections results in long COVID, thus affecting about 65 million people worldwide.
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3D illustration of organoid models in a petri dish
Neonatal/Pediatrics

3D organoids arising from amniotic fluid cells may be a potent prenatal tool

March 8, 2024
By Xavier Bofill Bruna
Organoids are 3D models created from human stem cells and resemble fetal tissues. In an article published in Nature Medicine on March 4, 2024, researchers from University College London provided details on the possibility of generating organoids from epithelial cells collected from amniotic fluid without terminating the pregnancy.
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Neonatal/Pediatrics

3D organoids arising from amniotic fluid cells may be a potent prenatal tool

March 5, 2024
By Xavier Bofill Bruna
Organoids are 3D models created from human stem cells and resemble fetal tissues. In an article published in Nature Medicine on March 4, 2024, researchers from University College London provided details on the possibility of generating organoids from epithelial cells collected from amniotic fluid without terminating the pregnancy.
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Ribosome as part of an biological cell constructing mRNA molecules
Infection

Ribosome-binding antibiotic cresomycin strikes against multidrug-resistant pathogens

Feb. 22, 2024
By Xavier Bofill Bruna
Researchers from the University of Illinois at Chicago and Harvard University have published details on the chemical synthesis and microbiological evaluation of a ribosome-binding antibiotic – cresomycin (CRM) – that was able to overcome antimicrobial resistance of major pathogenic bacteria including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and others.
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Artwork depicts KIBRA-dependent recovery of functional plasticity at synapses despite tau-induced toxicity in the brain.
Neurology/Psychiatric

KIBRA restores tau-driven damage in Alzheimer’s disease

Feb. 6, 2024
By Xavier Bofill Bruna
It is well known that protein tau forms aggregates in the brain in neurodegenerative diseases such as Alzheimer’s disease (AD) that are also known as tauopathies. Accumulation of protein tau in the brain leads to the cell toxicity and promotes the loss of synaptic plasticity, which in turn causes memory loss. As reported on Feb. 1, 2024, in The Journal of Clinical Investigation, assistant professor Tara Tracy and her research team from the Buck Institute for Research on Aging have discovered a protein in the brain that could restore this damage induced by protein tau.
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Villi in intestinal tract.
Immuno-oncology

Targeting CTLA-4 without colitis induction is gut microbiota dependent

Jan. 16, 2024
By Xavier Bofill Bruna
Immune checkpoint inhibitors (ICIs), such as anti-CTLA-4 antibodies, are widely used in cancer immunotherapy. CTLA-4 blockers such as Yervoy (ipilimumab, Bristol Myers Squibb Co.) stimulate antitumoral immune responses, but may also induce toxicity, such as colitis, a common immune-related adverse event that can lead to treatment discontinuation.
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View All Articles by Xavier Bofill Bruna

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