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Home » Authors » Lee Landenberger

Articles by Lee Landenberger

Kiniksa gets $100M up front from Genentech for monoclonal antibody

Aug. 3, 2022
By Lee Landenberger
Genentech Inc. is paying Kiniksa Pharmaceuticals Ltd. $100 million in up-front and near-term payments for the development and commercialization rights to vixarelimab, a fully human monoclonal antibody. Kiniksa also could receive up to approximately $600 million in certain clinical, regulatory and sales-based milestones, as well as royalties on annual net sales.
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Handshake dollar sign

Back for more: Sosei and Abbvie cut another $1B+ deal

Aug. 2, 2022
By Lee Landenberger
Sosei Heptares and Abbvie Inc. have built on the huge, multitarget deal they cut a little more than two years ago by signing another one.
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AZ’s phase III with Innate halted due to lack of efficacy

Aug. 1, 2022
By Lee Landenberger
After spending a lot of money and putting in seven years of hard work, Astrazeneca plc is discontinuing its phase III Interlink-1 study of monalizumab. Results from an interim futility analysis and an independent data monitoring committee’s recommendation convinced the company to bring it to a halt.
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Tense times: Vistagen phase III in social anxiety disorder misses primary endpoint

July 22, 2022
By Lee Landenberger
Top-line results from Vistagen Therapeutics Inc.’s Palisade-1 phase III study of PH-94B for treating social anxiety disorder showed the therapy fell shy of the primary endpoint. The South San Francisco-based company’s stock (NASDAQ:VTGN) fell dramatically on the results July 22 as shares closed 86% lower at 15 cents each.
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Dollar sign dropper and test tube

Keeping busy, Verve does a $500M deal with Vertex

July 21, 2022
By Lee Landenberger
Verve Therapeutics Inc. has packed a lot into the past few weeks. The latest is a four-year research deal with Vertex Pharmaceuticals Inc. to find and develop an in vivo gene editing program for an undisclosed liver disease. Vertex will pick up the tab for program costs as Verve does the preclinical R&D. Verve is getting an up-front $60 million from Vertex, along with a $35 million equity investment.
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Ovarian cancer illustration

VBL’s phase III of ofra-vec misses in ovarian cancer, dragging the stock with it

July 20, 2022
By Lee Landenberger
VBL Therapeutics Inc.’s phase III study of its gene therapy, ofranergene obadenovec, in treating ovarian cancer missed its primary endpoints, prompting the company to discontinue the trial and investors to pull way back. Shares of the Tel Aviv, Israel, and New York-based company’s stock (NASDAQ:VBLT) plunged 79% on July 20 to close at 43 cents per share. The $1.62 per share drop in value made it a penny stock. VBL shares hit their high on Nov. 8, closing at $2.53 each. Top-line data for ofra-vec, also known as VB-111, showed no statistically significant improvement in progression-free survival or overall survival.
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New data and an acquisition can’t strengthen Ultragenyx stock

July 19, 2022
By Lee Landenberger
New interim data from Ultragenyx Pharmaceutical Inc. and Genetx Biotherapeutics LLC’s phase I/II study of GTX-102 in Angelman’s syndrome didn’t do much to bolster investor confidence, as Ultragenyx shares sagged considerably July 19. The Novato, Calif.-based company’s stock (NADAQ:RARE) closed 13% downward at $52.89 per share. That is nearly half the price shares fetched in late August. At $102.40 per share, that was the stock’s highest value in the past 12 months.
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AAV 3D illustration

Avista’s AAV deal with Roche could bring in more than $1B

July 19, 2022
By Lee Landenberger
Recently launched and relatively small Avista Therapeutics Inc. has just cut a deal with comparatively massive Roche Holding AG that could bring the new Pittsburgh-based company more than $1 billion.  Avista’s single cell adeno-associated virus (AAV) platform will be used to develop intravitreal AAV capsids that match a Roche-defined capsid profile. Roche will evaluate and license Avista’s capsids and conduct the preclinical, clinical and commercialization work for the gene therapy programs.
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Gene editing illustration
Newco news

CRISPR co-inventor’s Epic Bio launches with $55M series A

July 15, 2022
By Lee Landenberger
Controlling the epigenetics of a patient, figuring out what genes are expressed and understanding their level of expression, is at the center of Epic Bio, a new company founded by Stanley Qi, co-inventor on the CRISPR patent held by the University of California.
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After its EUA, Novavax awaits CDC guidance before going to market

July 14, 2022
By Lee Landenberger
Now that Novavax Inc. has received an emergency use authorization (EUA) from the U.S. FDA allowing adults to receive the adjuvanted vaccine to ward off severe acute COVID-19, it’s time for the CDC to weigh in. Once its Advisory Committee on Immunization Practices meets July 19 to discuss the vaccine and make a policy recommendation, the vaccine will be available on the market.
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