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Home » Blogs » BioWorld Perspectives

BioWorld Perspectives
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Building a wall to keep companies in

April 5, 2016
By Mari Serebrov
They may not realize it, but many Americans woke up this morning with their retirement portfolio worth less than it was a week ago. And it could be worth less tomorrow and even a year or a decade from now than it would have been – all because of Monday’s unilateral decision by the Department of Treasury to build an even higher wall, at the expense of investors, to keep U.S. businesses from moving out of the country. The investors most affected by the decision won’t be found on any Forbes list of the richest of the rich. They can’t...
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Ignoring the science for a bigger box of crayons

March 8, 2016
By Mari Serebrov
Once upon a time in the days before enlightenment, we tried to use science to develop our drugs. Believe it or not, researchers actually had to come up with a hypothesis of how a drug might work, what disease it might tackle and who it might work for – before testing it in a crayon box of humans. In the early days, the focus was on drugs that worked for the average patient. In their rush to develop these drugs, sponsors were exclusive, almost elitist – some would say even discriminatory – in the patients they allowed in their clinical...
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Shkreli: A supervillain with a dastardly plan? Or a distraction from the real problem?

Feb. 9, 2016
By Jennifer Boggs
As the saga of Martin Shkreli continues to unfold in all its obnoxious glory, with every tweet and smirk signifying the former biopharma CEO’s apparent aspirations to a level of sheer jerkiness heretofore unseen on planet Earth, there’s one question that I – and probably a lot of other folks – can’t help but ask: Is this guy for real? I mean, seriously? From his gleefully unapologetic, 5,500-percent price hike for an in-licensed, generic drug, to his now-infamous gray-hoodied perp walk following his arrest on charges of securities fraud, to his juvenile Twitter taunts – not to mention his outlandish...
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No joy in Bio-ville

Dec. 30, 2015
By Mari Serebrov
Whether naughty or nice in 2015, Drugmakers received not what they wanted And not what they needed, For the biggest “must-haves” on their wish list Went mostly unheeded.   At the top of that list, and repeated quite often, Was a gift to undo the threat to their patents From that monster of monsters, the IPR Grinch. But 2015 came and is going, with no help in sight, no relief from a mensch.   Second in line, but no less desired, Was prayer for relief From a CMS mire. Part B biosimilars must not – no, they must NOT  –...
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May the fun be with you: BioWorld’s 9th annual Holiday Gift Guide

Nov. 25, 2015
By Marie Powers
Let’s face it, Star Wars references are unavoidable in this year’s holiday gift guide. Not convinced? I find your lack of faith disturbing. Several members of our intrepid staff and respondents to our annual poll gave a nod to the awakening force. Jennifer Boggs, BioWorld’s managing editor, was lamenting about holiday gifts like toasters that are practical but, let’s just say, not very exciting when she discovered “there are some cool toasters after all. I stand corrected.” Her find was the Star Wars Darth Vader toaster, a true likeness of the famously redeemed villain, although you’ll have to look for...
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An inconvenient truth

Nov. 10, 2015
By Mari Serebrov
Too often, drugmakers confuse convenience with quality of life, investing untold R&D resources in devising longer-acting formulations and then calling it “innovation.” The only innovation is in how it fends off competition by extending their patent protection. Such “advances” ignore what truly matters to patients. For cancer patients who are so weakened by drugs that they don’t have the strength to roll over in bed or get out of a chair, taking a medicine once a day or twice a day makes no difference. All they want is their life back. They want to have the strength to hug their...
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Precision medicine in the real world

Oct. 1, 2015
By Mari Serebrov
In a perfect world, doctors would have the diagnostics to determine the right treatment for each patient at the right dose and the right time. It would be called precision medicine. In our world, researchers, doctors and patients are teased by the hope of precision medicine, as investment dwindles for the development of the diagnostics necessary to turn hope into reality. No incentives encourage that investment. Court rulings have rendered most diagnostics unpatentable. The FDA offers no exclusivity. And now Medicare is proposing drastic reimbursement cuts for diagnostic tests. In a perfect world, life-saving drugs would be affordable. Congress and...
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Better Rx needed to treat drugmakers’ PR malady

Sep. 22, 2015
By Mari Serebrov
Biopharma has a bad PR disease. The diagnosis is pretium offensus, otherwise known as “sticker shock.” The infectious condition has two causes: enormous, inexplicable, overnight price hikes and six-figure drug prices that spread from headlines to become a viral meme in congressional hearings and social media. The symptoms are a growing distrust of drugmakers, demands for comparative effectiveness-based pricing, calls for government price controls and, in an election year, much-hyped presidential campaign promises to curb the “skyrocketing costs of prescription drugs.” The prognosis is disastrous for everyone affected. Industry is responding, but its Rx isn’t working. Historic trending charts, comparisons...
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Lessons learned from You-Know-Who

Sep. 2, 2015
By Mari Serebrov
Duchesnay Inc.’s 15-minutes of fame for its morning sickness drug arguably turned into a few hours’ worth by time the drugmaker complied with an FDA warning letter demanding a corrective ad to offset the omission of risk information in paid social media endorsements by She-Who-Must-Not-Be-Named in the serious biopharma world. The first 15 minutes for Diclegis (doxylamine succinate and pyridoxine hydrochloride)came with You-Know-Who’s tweets and posts to her millions of followers on Facebook and Instagram. That fame increased exponentially when the FDA handed down the warning letter last month, daring to name the infamous reality TV maven and setting mainstream...
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The next episode of the American horror story

July 24, 2015
By Mari Serebrov
You’ve likely heard the terrified screams induced by the cost of pricey cancer drugs, Gilead Sciences Inc.’s twin hepatitis C therapies and Vertex’s cystic fibrosis breakthroughs. And you may have been rattled by the nightmarish predictions about how a new class of cholesterol-lowering drugs – PCSK9 inhibitors – is going to break the U.S. health care bank. But those tales from the script are nowhere near as frightening as the potential price for the first effective new Alzheimer’s drug to hit the market. Given the 99 percent fail rate of wannabe Alzheimer’s treatments and the dark shadow the disease casts...
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