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Home » Keywords » psilocybin

Items Tagged with 'psilocybin'

ARTICLES

Illustration of scary hand overshadowing crouching girl
Neurology/psychiatric

Psychedelics modulate neuroimmune interactions that control fear

April 28, 2025
By Mar de Miguel
Research of the neuroimmune mechanisms involved in stress-related fear revealed how astrocytes interact with neurons in the amygdala. The study, led by Harvard scientists, also unveiled that this interaction recruited monocytes to the meninges during chronic stress and showed how psychedelic compounds reversed monocyte accumulation in the meninges and reduced fear behavior.
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Therapeutic trends 2024 - psychedelics

Credibility gap closing for psychedelics

Jan. 3, 2025
By Randy Osborne
Psychedelic drugs continued to make regulatory and clinical headway, as non-believers converted to believers in the category once regarded with skepticism, to say the least.
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Relmada turns to metabolic disease after latest depression miss

Dec. 4, 2024
By Jennifer Boggs
Shares of Relmada Therapeutics Inc. (NASDAQ:RLMD) plummeted 77% to close at 63 cents Dec. 4 after a pre-planned interim analysis prompted the independent data monitoring committee to conclude the phase III Reliance II study testing REL-1017 in major depressive disorder is likely to fail, leaving the future of the NMDA receptor channel blocker in doubt while the company looks ahead to an earlier-stage psilocybin-based program targeting metabolic disease.
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Woman holding neck in pain

Good Tryp: Psilocybin trial brings pain relief for fibromyalgia

Aug. 27, 2024
By Tamra Sami
All patients dosed in a phase IIa trial with Tryptamine Therapeutics Ltd.’s (Tryp) oral psilocybin (TRP-8802) trial reported an improvement in fibromyalgia pain severity, sleep, and pain interference.
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Woman holding neck in pain

Good Tryp: Psilocybin trial brings pain relief for fibromyalgia

Aug. 26, 2024
By Tamra Sami
All patients dosed in a phase IIa trial with Tryptamine Therapeutics Ltd.’s (Tryp) oral psilocybin (TRP-8802) trial reported an improvement in fibromyalgia pain severity, sleep, and pain interference.
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Top Trends Therapeutics, pill, syringe

Psychedelic-assisted therapy: The state of play in Europe

Dec. 21, 2023
By Nuala Moran
Following the decision of Australia’s Therapeutic Drugs Administration to allow prescribing of MDMA for post-traumatic stress disorder and psilocybin in treatment-resistant depression from July 2023, and with U.S. FDA approval of MDMA for treating PTSD expected in 2024, the EMA is under increasing pressure to set out a path to approval for psychedelics.
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Brain activity concept illustration
Newco news

Enveric Biosciences gears up for phase I anxiety trial with psilocin prodrug

June 27, 2023
By Tamra Sami
Enveric Biosciences Inc. is gearing up to begin clinical trials in generalized anxiety disorder with lead candidate, EB-373, a psilocin prodrug. Trials are expected to begin in the fourth quarter of 2023.
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Brain activity concept illustration
Newco news

Enveric Biosciences gears up for phase I anxiety trial with psilocin prodrug

June 22, 2023
By Tamra Sami
Enveric Biosciences Inc. is gearing up to begin clinical trials in generalized anxiety disorder with lead candidate, EB-373, a psilocin prodrug. Trials are expected to begin in the fourth quarter of 2023.
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Joel Latham, CEO, Incannex Healthcare Ltd.
Newco news

Incannex is changing treatment paradigms with pipeline of psychedelics and cannabinoids

June 6, 2023
By Tamra Sami
Incannex Healthcare Ltd. had quietly been developing its commercialization plans for psychedelic clinics well before Australia’s Therapeutic Goods Administration announced it would allow psilocybin and MDMA (3,4-methylenedioxy-methamphetamine) to be prescribed by authorized psychiatrists for treatment-resistant depression and post-traumatic stress disorder.
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Neurology/Psychiatric

Psychedelic drugs activate an antidepressant pathway without hallucinogenic effects

June 6, 2023
By Mar de Miguel
Psychedelic drugs could have two distinct overlapping effects based on their affinity for two receptors involved in neuronal plasticity. Scientists at the University of Helsinki have observed that lysergic acid diethylamide (LSD) and psilocin (a drug isolated from the mushroom Psilocybe mexicana) have an antidepressant effect that is independent of their hallucinogenic outcome. These two different pathways are established through their binding to the tyrosine kinase receptor (TrkB), which has an antidepressant nature, or to the serotonin receptor, with a hallucinogenic activity.
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