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Home » Keywords » CRISPR

Items Tagged with 'CRISPR'

ARTICLES

Transmission electron micrograph of HIV-1 virus particles
HIV/AIDS

IAS 2025: Cheat, parasitize, break the virus – fresh ideas fuel HIV research

July 21, 2025
No Comments
There is still no effective vaccine or cure for HIV. Scientists are considering options ranging from longer-term antiretroviral therapy (ART) that space out injections by several years to long-lasting pre-exposure prophylaxis (PrEP) that acts as a vaccine while immunization is achieved. What else can be done?
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Transmission electron micrograph of HIV-1 virus particles
HIV/AIDS

IAS 2025: Cheat, parasitize, break the virus – fresh ideas fuel HIV research

July 18, 2025
No Comments
There is still no effective vaccine or cure for HIV. Scientists are considering options ranging from longer-term antiretroviral therapy (ART) that space out injections by several years to long-lasting pre-exposure prophylaxis (PrEP) that acts as a vaccine while immunization is achieved. What else can be done? The “Innovations in HIV virology: Translating discoveries into novel therapies” symposium in basic science at the 13th IAS Conference on HIV Science (IAS 2025), which took place from July 13 to 17, 2025, in Kigali, Rwanda, showcased some of the new ideas that the scientific community are developing.
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AI-generated illustration of CAR T cells
Immuno-oncology

Researchers arm CAR T cells to fight solid tumors

July 8, 2025
By Tamra Sami
No Comments
Aussie researchers have used CRISPR gene editing tools to “armor” chimeric antigen receptor (CAR) T cells to activate additional cancer-fighting proteins at the tumor site, enabling them to target cancer cells in solid tumors.
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AI-generated illustration of CAR T cells
Immuno-oncology

Researchers arm CAR T cells to fight solid tumors

July 3, 2025
By Tamra Sami
No Comments
Aussie researchers have used CRISPR gene editing tools to “armor” chimeric antigen receptor (CAR) T cells to activate additional cancer-fighting proteins at the tumor site, enabling them to target cancer cells in solid tumors.
Read More

Nex-z phase III enzyme dime-drop chops Intellia in ATTR-CM

May 29, 2025
By Randy Osborne
No Comments
Investors found in an 8-K filing by Intellia Therapeutics Inc. the news of one case of liver-enzyme elevation in the ongoing phase III Magnitude study with nexiguran ziclumeran (nex-z, NTLA-2001), and in reaction pushed shares of the firm (NASDAQ:NTLA) down to close May 29 at $7.45, a loss of $2.21, or 23%, after the stock traded as low as $6.90 during the day.
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Gene editing illustration
Infection

New CRISPR-based antiviral strategy targets neurotrophic JC polyomavirus in 2D and 3D cell models

May 26, 2025
No Comments
Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system caused by lytic infection of oligodendrocytes by pathogenic strains of the JC polyomavirus (JCV). This opportunistic virus has long persisted as a serious threat during periods of immunosuppression, and currently, there is no effective antiviral treatment available.
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DNA in test tubes
Neurology/psychiatric

Preclinical data reported for LETI-101 show allele selective editing and mHTT reduction

March 13, 2025
Researchers from Life Edit Therapeutics Inc. recently reported preclinical data on the application of their gene editing technology Life Edit CRISPR system to Huntington’s disease (HD).
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DNA in drug capsules

Alliance for Regenerative Medicine: Field growing, cost still an issue

Jan. 14, 2025
By Nuala Moran
The accelerating pace of U.S. FDA approvals for cell and gene therapies is “great for the field and great news for the patients,” but questions remain over commercialization, with “costs remaining stubbornly high.” That was the glass half-full summary of Tim Hunt, president of the industry group, the Alliance for Regenerative Medicine, reprising progress in 2024, and looking forward to the prospects for further growth and the potential impact of the incoming Trump administration in 2025.
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Mammoth gets $95M from Regeneron in CRISPR/gene-editing deal

April 25, 2024
By Lee Landenberger
Seven years after embarking on in vivo therapeutic development using CRISPR/Cas gene-editing technology with Intellia Therapeutics Inc., Regeneron Pharmaceuticals Inc. is bringing another company into the collaborative fold. Regeneron will pay Mammoth Biosciences Inc. $100 million, including $95 million as an equity investment, and an up-front payment. Mammoth also could bring in up to $370 million for each target in milestones along with royalties on net sales from products created through the collaboration.
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Gene editing illustration
Cancer

Akribion successfully synthesizes constructs combining its G-dase E nuclease with Transcode’s TTX platform

March 12, 2024
Transcode Therapeutics Inc. has reported promising proof-of-concept laboratory studies in human cells, advancing its strategic partnership with Akribion Genomics AG.
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