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Home » Keywords » epilepsy

Items Tagged with 'epilepsy'

ARTICLES

Conceptual image for brain cancer treatment
Biomarkers

miR-1290 predicts seizure susceptibility in glioblastoma patients

May 21, 2025
No Comments
Glioblastoma (GBM) is an aggressive cancer from the CNS usually characterized by a very bad prognosis. It is known that around 30%-35% of patients with GBM develop epilepsy as a comorbidity of the disease.
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Illustration of brain and brain waves, concept of focal seizure

FOS-tering patience: Xenon moves azetukalner data to next year

May 13, 2025
By Randy Osborne
No Comments
Xenon Pharmaceuticals Inc. is delaying the phase III data readout from the X-tole2 trial with azetukalner in focal onset seizures (FOS) from the second half of 2025 to early 2026 but remains busy with NDA plans.
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Pediatric brain illustration
Neurology/psychiatric

Capsida’s gene therapy for STXBP1 developmental and epileptic encephalopathy gains IND clearance

May 13, 2025
No Comments
Capsida Biotherapeutics Inc. has gained IND clearance from the FDA for CAP-002, its first-in-class, intravenously administered gene therapy for syntaxin-binding protein 1 developmental and epileptic encephalopathy (STXBP1-DEE). Dosing in the phase I/IIa SYNRGY trial will begin in the third quarter of this year.
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Neurology/psychiatric

GW Research discovers new cannabinoid compounds to treat epilepsy and seizures

April 29, 2025
GW Research Ltd. has described cannabinoid compounds reported to be useful for the treatment of epilepsy and seizures.
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Mark Cook with Minder implant

Epiminder wins de novo clearance for epilepsy EEG monitor

April 24, 2025
By Tamra Sami
The U.S. FDA has granted de novo clearance for Epiminder Pty. Ltd.’s Minder implantable device for continuously monitoring brain activity in patients with epilepsy.
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Neurology/psychiatric

FKBP51 induces astrogliosis and seizures through NF-κB signaling, study shows

April 15, 2025
The etiology of epilepsy, as well as its pathology, still remains evasive. The role that FK506-binding protein 51 (FKBP51) might play in this disease was investigated in a murine model of kainic acid-induced excitotoxic brain injury.
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Neurona closes a $102M financing

April 4, 2025
By Lee Landenberger
Neurona Therapeutics Inc. has completed an upsized, oversubscribed $102 million financing round, the third company to do so in a month that’s only four days old. The privately held company’s lead asset is NRTX-1001, a regenerative cell therapy derived from human pluripotent stem cells. 
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Neurology/psychiatric

New preclinical data on NKCC1 inhibitor IAMA-6 in neurological disorder models

April 3, 2025
Growing evidence exists on regulation of the chloride importer solute carrier family 12 member 2 (SLC12A2), also known as NKCC1, as a therapeutic approach to treat neurological disorders. Altered expression of NKCC1 leads to impaired intracellular chloride levels in neurons and imbalance in the excitatory-inhibitory axis in the brain.
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Brain maze
Neurology/psychiatric

Iqure’s EAAT2 modulator gains IRB clearance for first-in-human study

March 17, 2025
Iqure Pharma Inc. has received institutional review board (IRB) approval for a first-in-human study of iQ-007 in healthy volunteers. This follows recent formal approval from the Human Research Ethics Committee (HREC) in Australia for the phase I study, which is expected to begin next month.
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Neurology/psychiatric

Selene Therapeutics describes new brain permeable DHODH inhibitors

March 14, 2025
Selene Therapeutics Ltd. has identified brain permeable dihydroorotate dehydrogenase (DHODH) inhibitors reported to be useful for the treatment of epilepsy, cancer, Alzheimer’s disease, rheumatoid arthritis and multiple sclerosis.
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