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BioWorld - Sunday, July 6, 2025
Home » Keywords » primary sclerosing cholangitis

Items Tagged with 'primary sclerosing cholangitis'

ARTICLES

Liver
Gastrointestinal

Dual-targeted approach for hepatobiliary diseases presented

Nov. 28, 2024
Rectify Pharmaceuticals Inc. has conducted preclinical testing on RTY-694, an oral dual-targeted positive functional modulator for use in the treatment of hepatobiliary disorders.
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Liver anatomy illustration
Gastrointestinal

Rectify nominates development candidate for primary sclerosing cholangitis

Oct. 23, 2024
Rectify Pharmaceuticals Inc. has nominated the positive functional modulator (PFM) RTY-694 as a development candidate for primary sclerosing cholangitis (PSC). As the lead PFM in Rectify’s hepatobiliary program, RTY-694 is now advancing to first-in-human trials for PSC.
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Liver
Immune

PVT-201 gets US orphan status, cleared for Aussie trial

July 30, 2024
Parvus Therapeutics Inc.'s PVT-201 has received orphan drug status from the U.S. FDA for the treatment of primary biliary cholangitis (PBC), an autoimmune disease of the liver.
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Deal handshake with coin, chart background

Aprilbio, Evommune strike $475M deal for autoinflammatory drug

June 25, 2024
By Marian (YoonJee) Chu
Aprilbio Co. Ltd. saw its stock surge 30% June 20 after announcing a potential $475 million (₩655.88 billion) deal with Evommune Inc. for autoimmune disease drug candidate APB-R3.
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Deal handshake with coin, chart background

Aprilbio, Evommune strike $475M deal for autoinflammatory drug

June 21, 2024
By Marian (YoonJee) Chu
Aprilbio Co. Ltd. saw its stock surge 30% June 20 after announcing a potential $475 million (₩655.88 billion) deal with Evommune Inc. for autoimmune disease drug candidate APB-R3.
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IBAT they can: Mirum’s volixibat wins in PBC, PSC validate hope

June 17, 2024
By Randy Osborne
Optimism on Wall Street proved wise and shares of Mirum Pharmaceuticals Inc. (NASDAQ:MIRM) rose accordingly to close June 17 at $33, up $7.08, or 27.3%, as the firm disclosed interim results from two phase IIb studies evaluating volixibat, an oral ileal bile acid transporter (IBAT) inhibitor, in patients with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). The drug proved its mettle in both liver biliary tract-stenosing indications, with no new safety signals turning up, Foster City, Calif.-based Mirum said.
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Respiratory

Shanghai Rulink Biopharma divulges new integrin αvβ1, αvβ6 and αvβ8 antagonists

May 21, 2024
Shanghai Rulink Biopharma Co. Ltd. has synthesized integrin αvβ1, αvβ6 and/or αvβ8 antagonists reported to be useful for the treatment of idiopathic pulmonary fibrosis and primary sclerosing cholangitis.
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Liver

Pliant dips on positive phase II data with bexotegrast in PSC

Feb. 5, 2024
By Randy Osborne
As the company’s phase II study in idiopathic pulmonary fibrosis continues, Pliant Therapeutics Inc.’s investors looked hard at 12-week interim data from the 320-mg dose group of Integris-PSC, a multinational, randomized, double-blind, placebo-controlled phase II trial testing bexotegrast in primary sclerosing cholangitis and suspected moderate to severe liver fibrosis.
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Liver anatomy illustration
Biomarkers

Study finds TNFRSF14 and LIGHT levels are elevated in primary sclerosing cholangitis

May 9, 2023
There is still a lack of specific biomarkers in biliary epithelial cells of patients with primary sclerosing cholangitis (PSC). Investigators from the...
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Liver anatomy illustration
Biomarkers

Identification of new risk-associated loci in primary sclerosing cholangitis

March 3, 2023
Primary sclerosing cholangitis (PSC) is a rare chronic and progressive autoimmune bile duct disease that is strongly associated with several immune-mediated disorders, the shared etiology and underlying characteristics of which is not completely understood. Researchers from Baylor College of Medicine investigated the shared genetic architecture of PSC with a variety of clinical and epidemiological traits and aimed to identify new lead PSC risk-associated loci.
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More Articles Tagged with 'primary sclerosing cholangitis'

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