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Home » Keywords » rheumatoid arthritis

Items Tagged with 'rheumatoid arthritis'

ARTICLES

Musculoskeletal

Targeting TREX1 enhances cell-free DNA degradation

July 25, 2025
No Comments
Rheumatoid arthritis is a chronic, systemic autoimmune disease characterized by systemic inflammation and progressive joint destruction. Current treatments include conventional disease-modifying antirheumatic drugs and biologics. However, long-term treatment is frequently associated with drug resistance and significant adverse effects.
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Musculoskeletal

New tracer has diagnostic utility for rheumatoid arthritis

June 17, 2025
No Comments
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and damage of the joints. PET/CT imaging is a useful tool for early disease assessment and monitoring treatment efficacy.
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Lab glassware and antibodies art concept
Immune

Glucocorticoid ADC targets immune cells in disease models

June 17, 2025
No Comments
Researchers from Lifordi Immunotherapeutics Inc. have developed a novel antibody-drug conjugate (ADC) called LFD-200 that aims to selectively deliver a potent glucocorticoid (GC) payload directly to immune cells. This strategy may potentially offer a new way to treat autoimmune and inflammatory conditions while minimizing systemic toxicity.
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Close up of senior man holding wrist of arthritic hand
Musculoskeletal

CXCR7 agonist to mitigate rheumatoid arthritis

June 16, 2025
No Comments
Researchers at Ileadbms Co. Ltd. have announced promising results of their novel drug IL-21120033 in a preclinical model of rheumatoid arthritis. The drug acts as a selective agonist of the chemokine receptor CXCR7.
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Photo of older woman holding hand that's colored red
Dermatologic

Strong JAK1-selective inhibitor IN-115314: pharmacokinetics and -dynamics in dogs

May 23, 2025
No Comments
Rheumatoid arthritis, atopic dermatitis, ulcerative colitis and several other inflammatory diseases involve hyperactivation of JAK-STAT signaling, in which the kinase JAK binds and phosphorylates the transcription factor STAT, which then turns on gene expression.
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Art concept for inflamed human tissue
Immune

Kymera unveils new oral IRF5 degrader for immuno-inflammatory diseases

May 12, 2025
No Comments
Kymera Therapeutics Inc. has announced a new oral IRF5 degrader program with potential to treat immuno-inflammatory diseases, such as lupus, Sjögren’s syndrome, rheumatoid arthritis and inflammatory bowel disease.
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Vaccination
Musculoskeletal

New tolerogenic antigen-specific vaccine boosts VISTA+ Tregs and prevents arthritis in RA model

April 29, 2025
Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by joint inflammation, cartilage loss and bone damage. Although biological disease-modifying antirheumatic drugs have improved treatment outcomes, the disease remains incurable.
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Musculoskeletal

Bristol Myers Squibb discloses new PAD4 inhibitors for rheumatoid arthritis

Feb. 12, 2025
Bristol Myers Squibb Co. has patented new protein-arginine deiminase type-4 (PADI4; PAD4) inhibitors reported to be useful for the treatment of rheumatoid arthritis, among others.
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Musculoskeletal

Xi’an Xintong Medicine Research divulges new JAK3 inhibitors

Jan. 27, 2025
Xi’an Xintong Medicine Research Co. Ltd. has synthesized tyrosine-protein kinase JAK3 inhibitors reported to be useful for the treatment of rheumatoid arthritis, alopecia areata, vitiligo, asthma, chronic obstructive pulmonary disease, cancer and inflammatory bowel disease.
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Musculoskeletal

Series A financing at Rheumagen supports HLA gene-editing therapies for autoimmune diseases

Jan. 10, 2025
The financing will enable progression of RG-0401.
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More Articles Tagged with 'rheumatoid arthritis'

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