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Home » Keywords » CAR T

Items Tagged with 'CAR T'

ARTICLES

Immuno-oncology

Improving CAR T cell performance 'ALA-CART'

April 11, 2025
Although CD19-directed CAR T cells can initially induce remission in 70-90% of patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL), post-CAR relapses are frequent. These relapses are driven by insufficient persistence of CAR T cells, allowing for antigen-positive B-ALL re-emergence and loss of the targeted epitope either in isolation or as part of lineage-switching.
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M&A letters over missing puzzle pieces

Roche snaps up Poseida for $1.5B

Nov. 26, 2024
By Lee Landenberger
Poseida Therapeutics Inc. is being bought out for $1.5 billion by partner Roche Holdings Inc. to develop allogeneic CAR T therapies to treat hematologic malignancies. The two companies began their collaboration in August 2022, a deal that brought Poseida $110 million up front and another $110 million in near-term milestone payments. With the acquisition, Roche plans to develop CAR T programs for solid tumors and autoimmune diseases with Poseida's genetic engineering platform and preclinical programs.
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3D illustration of acute myeloid leukemia cells
Immuno-oncology

Hemogenyx gains IRB approval for trial of HEMO-CAR-T for AML

Nov. 25, 2024
Hemogenyx Pharmaceuticals plc has obtained approval by the institutional review board (IRB) of the company’s first clinical site to initiate a phase I trial of the company’s lead asset, HEMO-CAR-T, for the treatment of relapsed or refractory acute myeloid leukemia (AML) in adults.
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FDA lifts clinical hold on Carsgen’s CAR Ts following warnings

Nov. 12, 2024
By Tamra Sami
The FDA has lifted a clinical hold on Carsgen Therapeutics Holdings Ltd.’s. CAR T products after issuing the company a warning letter following a December 2023 FDA inspection that found the company violated good manufacturing practices at its Research Triangle Park facility in Durham, N.C.
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FDA lifts clinical hold on Carsgen’s CAR Ts following warnings

Nov. 6, 2024
By Tamra Sami
The FDA has lifted a clinical hold on Carsgen Therapeutics Holdings Ltd.’s. CAR T products after issuing the company a warning letter following a December 2023 FDA inspection that found the company violated good manufacturing practices at its Research Triangle Park facility in Durham, N.C.
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Sana cuts programs, staff, as it refocuses on autoimmune assets

Nov. 5, 2024
By Karen Carey
Extending its cash runway into 2026, Sana Biotechnology Inc. is prioritizing certain autoimmune assets and punting an oncology program and a central nervous system diseases program to a potential licensing partner or spinout company.
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CAR T cell with implanted gene strand

ECTRIMS 2024: Driving a fast CAR on the MS road and beyond

Sep. 23, 2024
By Coia Dulsat
Chimeric antigen receptor (CAR) T-cell therapy moved the needle at the 2024 ECTRIMS (European Committee for Treatment and Research in Multiple Sclerosis) congress and will continue to do so – not just in multiple sclerosis (MS), but in other autoimmune diseases as well.
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Biontech and Autolus collaborate to advance their CAR T programs

Feb. 8, 2024
By Lee Landenberger
Autolus Therapeutics Inc. has picked up plenty of financial momentum, about $600 million worth, in its runup to a November 2024 PDUFA date for its CD19 CAR T therapy. Helping propel that momentum is Biontech SE, another CAR T therapy developer. For $50 million cash, Biontech bought the rights to use Autolus’ manufacturing and commercial infrastructure in the U.K. so it can advance its CAR T-cell BNT-211 program in the clinic.
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3D illustration of B-cell lymphoma

Allogene first-line LBCL Foresight questioned, cheered as strategy shifts

Jan. 5, 2024
By Randy Osborne
Allogene Therapeutics Inc.’s decision to preferentially pursue first-line treatment of large B-cell lymphoma (LBCL) with CAR T cemacabtagene ansegedleucel (cema-cel, previously known as ALLO-501A) met mixed reviews on Wall Street.
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CAR T cell with implanted gene strand

ASH 2023: CAR T therapies take on autoimmune diseases

Dec. 11, 2023
By Brian Orelli
CAR T-cell therapies have worked well at curing blood malignancies, but a group out of the University Hospital of Erlangen have repurposed the technology as a treatment for autoimmune diseases. The expansion into new diseases has required cooperation between multiple departments, with CAR T experts taking the lead on treatment and potential side effects, and rheumatologists measuring the outcomes of the treatment.
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More Articles Tagged with 'CAR T'

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