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Home » Keywords » leukemia

Items Tagged with 'leukemia'

ARTICLES

Microscopic image of a Wilms tumor of a pediatric kidney

More mutations than previously thought in childhood cancers

May 30, 2025
By Nuala Moran
No Comments
Researchers in the U.K. have overthrown the orthodox view that childhood cancers have a low mutation burden, opening up new drug targets and opportunities for repurposing existing therapies. In particular, a high mutation rate is associated with a response to cancer immunotherapy. But although PD-1 checkpoint inhibitors are approved for treating pediatric cancers with a high level of microsatellite instability mutations, in general it is thought childhood tumors are not amenable to immunotherapy.
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Microscopic image of a Wilms tumor of a pediatric kidney

More mutations than previously thought in childhood cancers

May 29, 2025
By Nuala Moran
No Comments
Researchers in the U.K. have overthrown the orthodox view that childhood cancers have a low mutation burden, opening up new drug targets and opportunities for repurposing existing therapies. In particular, a high mutation rate is associated with a response to cancer immunotherapy. But although PD-1 checkpoint inhibitors are approved for treating pediatric cancers with a high level of microsatellite instability mutations, in general it is thought childhood tumors are not amenable to immunotherapy.
Read More
CAR T-cell therapy in acute lymphoblastic leukemia
Immuno-oncology

Third-generation K12 CAR T shows strong activity in CD7+ T-cell malignancies and relapsed AML

May 13, 2025
No Comments
A study has demonstrated the potential of a novel ligand-based CAR T-cell therapy for targeting CD7-positive T-cell malignancies, including T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphomas. The receptor CD7 is a prominent target antigen, being expressed in around 95% of T-ALL, 50% of peripheral T-cell lymphomas and 10% of acute myeloid leukemias.
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China adds Ascentage's lisaftoclax, olverembatinib to guidelines

April 29, 2025
By Tamra Sami
Ascentage Pharma Group Corp. Ltd. said two of its novel candidates have been included in the 2025 Chinese Society of Clinical Oncology Guidelines, including its in-house developed Bcl-2 selective inhibitor, lisaftoclax (APG-2575), which is under review in China and could be the first domestically approved Bcl-2 inhibitor and the second global approval.
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China adds Ascentage's lisaftoclax, olverembatinib to guidelines

April 23, 2025
By Tamra Sami
Ascentage Pharma Group Corp. Ltd. said two of its novel candidates have been included in the 2025 Chinese Society of Clinical Oncology Guidelines, including its in-house developed Bcl-2 selective inhibitor, lisaftoclax (APG-2575), which is under review in China and could be the first domestically approved Bcl-2 inhibitor and the second global approval.
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Art concept for hematologic cancer
Immuno-oncology

French grant supports Allogenica’s universal CAR T therapy for CD19-positive hematologic cancers

March 20, 2025
Allogenica SAS has been awarded a €2.5 million (US$2.7 million) grant under the French government’s France 2030 program to help advance its universal CAR T candidate, XL-001, for CD19-positive hematologic cancers.
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Cancer

US researchers divulge new FLT3 inhibitors for leukemia

March 5, 2025
Bioventures LLC and University of California have synthesized FLT3 (FLK2/STK1) inhibitors reported to be useful for the treatment of leukemia.
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Leukemia illustration
Cancer

Potent ASH1L inhibitor with strong antileukemic profile described

Feb. 3, 2025
The absent, small or homeotic-like 1 (ASH1L) protein regulates the expression of HOXA genes, which are critical for the development of MLL1 translocations frequently found in leukemia patients. Knockdown of ASH1L leads to growth arrest and apoptosis of leukemia cells, thereby inhibiting leukemia progression suggesting that ASH1L can be considered as a therapeutic target in this setting.
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Cancer

SIAIS-562055, a SOS1 PROTAC with activity in models of KRAS-mutant tumors and BCR-ABL-positive leukemia

Jan. 21, 2025
Son of sevenless homolog 1 (SOS1) is an essential guanine nucleotide exchange factor (GEF) in KRAS-driven tumors, and it also functions as a downstream node protein of BCR-ABL, suggesting its critical role in the pathogenesis of chronic myeloid leukemia (CML). Investigators at Shanghaitech University have reported the discovery and preclinical characterization of a novel potent SOS1 proteolysis targeting chimera (PROTAC) – SIAIS-562055 – being developed as an anticancer agent.
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Cancer

Potent, selective MTHFD2 inhibitor shows favorable PK and antitumor efficacy in AML models

Jan. 10, 2025
Scientists from Taiwan have detailed the discovery and characterization of new MTHFD2 inhibitors.
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