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Home » Keywords » B-cell non-Hodgkin lymphoma

Items Tagged with 'B-cell non-Hodgkin lymphoma'

ARTICLES

Colorized scanning electron micrograph of a B cell from a human donor.
Cancer

BMS-986458, a CRBN-mediated LDD targeting BCL6 for B-cell NHL treatment

March 31, 2025
At last week’s American Chemical Society Spring meeting, Bristol Myers Squibb Co. discussed the development of a potent, orally bioavailable and highly selective cereblon (CRBN)-mediated ligand-directed degrader (LDD) of B-cell lymphoma 6 protein (BCL6), BMS-986458, for the treatment of B-cell non-Hodgkin lymphoma.
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Businesswoman pressing dollar sign on touchscreen

Artiva prices $167M IPO as its AlloNK cell therapy advances

July 19, 2024
By Karen Carey
Artiva Biotherapeutics Inc. raised $167 million through an upsized IPO, with funds aimed at the development of its lead AlloNK program for systemic lupus erythematosus and other autoimmune indications. Just a few days ago, the San Diego based company had aimed to sell 8.4 million shares between $14 and $16 each, but it raised the number of shares offered to 13.92 million and lowered the price to $12 each. The upsize brings Artiva’s shares outstanding following the IPO to about 22.8 million, giving the company a market cap of $273.6 million based on the IPO price.
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Hey Cullinan plan: CLN-978’s new focus watering shares

April 16, 2024
By Randy Osborne
With an IND filing in systemic lupus erythematosus expected during the third quarter of 2024, Cullinan Therapeutics Inc. changed its name from Cullinan Oncology Inc. and detailed its plans to target autoimmune diseases with CLN-978, a CD19xCD3 T-cell engager.
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Non-Hodgkin lymphoma cells in the blood flow
Immuno-oncology

Verismo submits IND application for Synkir-310 for relapsed or refractory B-cell NHL

April 4, 2024
Verismo Therapeutics Inc. has submitted an IND application to the FDA seeking to initiate a phase I trial this year of Synkir-310 for the treatment of relapsed or refractory B-cell non-Hodgkin lymphomas (B-cell NHL), including diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma and marginal zone lymphoma.
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Cancer

Tarapeutics Science describes new PI3Kδ inhibitors

Nov. 22, 2023
Tarapeutics Science Inc. has identified phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitors reported to be useful for the treatment of cancer, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease (COPD) and systemic lupus erythematosus.
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Immuno-oncology

Qihan’s gene-edited iPSC-derived cell therapy product QN-019a allowed to enter clinic in China

July 19, 2023
Hangzhou Qihan Biotech Co. Ltd. has received clinical trial clearance from China’s National Medical Products Administration (NMPA) for QN-019a for CD19-positive relapsed/refractory aggressive B-cell non-Hodgkin lymphoma.
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Human natural killer cell
Immuno-oncology

IPH-6501, a CD20-targeting antibody-based NK-cell engager therapeutic for the treatment of B-NHL

June 19, 2023
Researchers from Innate Pharma SA recently presented preclinical data for IPH-6501, a novel CD20-targeting tetraspecific antibody-based natural killer (NK)-cell engager therapeutic being developed for the treatment of patients with B-cell non-Hodgkin lymphoma (B-NHL).
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Cancer

C4x Discovery's MALT1 inhibitor lead series shows reduced UGT1A1 inhibition at clinically meaningful doses

June 2, 2023
C4x Discovery Holdings plc has announced further progress in its MALT1 inhibitor program for cancer. Building on anti-cancer activity in a preclinical xenograft study, the company completed a preclinical study demonstrating its MALT1 lead compounds were free of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) liability shown by competitor chemistries. The program is continuing to identify a shortlist of preclinical candidates for further development, and a partnering program has been initiated.
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3D illustration of B-cell lymphoma
Immuno-oncology

Antengene’s anti-CD24 antibody ATG-031 cleared by FDA to enter clinic for solid tumors and B-NHL

May 18, 2023
Antengene Corp. Ltd. has received FDA clearance of its IND for a phase I study of the first-in-class...
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Non-Hodgkin lymphoma cells in the blood flow
Immuno-oncology

Cullinan's T-cell engager CLN-978 cleared by FDA to begin clinical studies for B-cell NHL

Jan. 25, 2023
The FDA has cleared Cullinan Oncology Inc.'s IND application for CLN-978, a CD19/CD3 T-cell engaging antibody construct with a human serum albumin (HSA) binding domain to increase serum half-life.
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More Articles Tagged with 'B-cell non-Hodgkin lymphoma'

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