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Home » Keywords » inflammatory bowel disease

Items Tagged with 'inflammatory bowel disease'

ARTICLES

Illustration of immunoglobulin A with secretory IgA
Gastrointestinal

NIH support for Lactiga’s sIgA antibody for IBD

Sep. 5, 2025
No Comments
Lactiga US Inc. has received an award from the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to advance the development of its secretory IgA (sIgA) antibody for inflammatory bowel disease (IBD).
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Probiotic gut bacteria

MRM raises $64M for ‘high performance teams of bacteria' in IBD

Sep. 4, 2025
By Nuala Moran
No Comments
The funding is in place for a phase IIb trial of its lead gut microbiome live biotherapeutic, after MRM Health NV closed a €55 million (US$64 million) series B round.
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Macrophage releasing cytokines as a part of the body's immune response.
Immune

Onco3r Therapeutics’ O3R-5671 cleared to enter clinic

Sep. 4, 2025
No Comments
Onco3r Therapeutics BV has obtained clinical trial application (CTA) approval by the Belgian regulatory authorities for its SIK3 inhibitor O3R-5671. A first-in-human trial will be conducted in Belgium and is expected to open enrollment in the coming weeks. Final data are expected in the first half of next year and will inform subsequent patient trials across a range of autoimmune diseases, which are planned to commence next year.
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Intestine
Gastrointestinal

Omass and Genentech partner in inflammatory bowel disease

Sep. 2, 2025
No Comments
Omass Therapeutics Ltd. has entered into an exclusive collaboration and license agreement with Genentech Inc., a member of the Roche Group, for the rights to develop and commercialize Omass’ preclinical oral small-molecule program for inflammatory bowel disease.
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3D illustration of human digestive system
Gastrointestinal

Preclinical profile of colon-targeted, pan-SIK inhibitor for IBD

Aug. 27, 2025
No Comments
Pfizer Inc. provided details on the discovery and in vitro/in vivo characteristics of SIK inhibitor PF-07899895 for the treatment of inflammatory bowel disease (IBD). Pfizer’s program focused on pan-SIK inhibition to regulate cytokine production in immune cells based on the hypothesis that this approach could suppress pro-inflammatory cytokines/chemokines and promote an anti-inflammatory phenotype.
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Illustration for inflammatory bowel disease
Gastrointestinal

IND open for Shattuck’s SL-325 for inflammatory bowel disease

Aug. 22, 2025
No Comments
Shattuck Labs Inc. has reported that its IND from the U.S. FDA for SL-325 for the treatment of inflammatory bowel disease is now in effect. The company expects to commence a phase I trial in healthy volunteers in the third quarter of this year.
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Gastrointestinal

Hefei Institutes of Physical Science divulges new PGK1 inhibitors

Aug. 7, 2025
Hefei Institutes of Physical Science Chinese Academy of Sciences has synthesized phosphoglycerate kinase 1 (PGK1) inhibitors reported to be useful for the treatment of inflammatory bowel disease.
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Stock chart, upward arrow

Abivax’s obefazimod wows investors; stock climbs 500%+

July 23, 2025
By Nuala Moran
No Comments
Abivax SA is positioning to change the treatment landscape in ulcerative colitis after delivering positive results and a favorable safety profile in two phase III trials of its orally available miRNA-124 enhancer, obefazimod. Abivax stock rocketed in Europe and the U.S. on news of the data. Shares (Paris:ABVX) rose €45.40, or 510%, to close at €54.30 July 23. In the U.S., shares (NASDAQ:ABVX) leapt 586%, or $58.60, to close at $68.60.
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New IBD strategies promising: Abivax, Shattuck, more

July 18, 2025
By Randy Osborne
No Comments
As Wall Street awaits key phase III data from Abivax SA with microRNA-124 (miR-124)-targeting obefazimod in ulcerative colitis, due this quarter, the inflammatory bowel disease (IBD) space – which also takes in Crohn’s disease – continues to grow and shift with new findings across varied fronts.
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Illustration of intestines with inflammation
Gastrointestinal

Engineered anti-IL-23 receptor antibody enables oral delivery to treat inflammatory bowel disease

June 19, 2025
No Comments
Researchers from Genentech Inc. have developed a novel single-domain antibody (VHH) targeting the IL-23 signaling pathway, which can be administered orally to effectively treat inflammatory bowel disease in animal models.
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More Articles Tagged with 'inflammatory bowel disease'

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