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BioWorld - Saturday, May 24, 2025
Home » Keywords » Staphylococcus aureus

Items Tagged with 'Staphylococcus aureus'

ARTICLES

Petri dishes

New drugs with the same old resistance tricks?

Jan. 21, 2025
By Coia Dulsat
According to the World Health Organization (WHO), multidrug-resistant pathogens caused over 1.27 million deaths worldwide in 2020. And figures are rising, with projections pointing to antimicrobial resistance surpassing cancer as the leading cause of death by 2050. Now, researchers at the HUN-REN Biological Research Center have unveiled the role of pre-existing genetic variabilities and specific cross-resistance patterns among several antibiotics designed to combat gram-positive bacteria.
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Petri dishes
Infection

New drugs with the same old resistance tricks?

Jan. 16, 2025
By Coia Dulsat
According to the World Health Organization (WHO), multidrug-resistant pathogens caused over 1.27 million deaths worldwide in 2020. And figures are rising, with projections pointing to antimicrobial resistance surpassing cancer as the leading cause of death by 2050. Now, researchers at the HUN-REN Biological Research Center have unveiled the role of pre-existing genetic variabilities and specific cross-resistance patterns among several antibiotics designed to combat gram-positive bacteria.
Read More
Staphylococcus aureus
Infection

New selective and potent ClpP agonist effectively targets S. aureus, including MRSA

Jan. 3, 2025
Caseinolytic protease P (ClpP) is a conserved serine protease present in both bacteria and humans, essential for maintaining protein quality by degrading misfolded proteins.
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Bacteria in petri dishes
Infection

MEK1/2 inhibitor shows antibacterial and anti-inflammatory effects

Oct. 7, 2024
It was hypothesized that the MEK1/2 inhibitor ATR-002 could reduce inflammation and clear Staphylococcus aureus infection during cystic fibrosis, thus potentially showing a dual effect.
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Bacterial colonies in petri dishes
Infection

Novel quinolone-derivative tackles microbial resistance

Aug. 26, 2024
The inappropriate use of antibiotics over long periods of time has led to increasing bacterial drug resistance. Quinolones are among the most effective and widely used antibacterials, and there are ongoing efforts to develop new quinolone-based drugs able to overcome emerging bacterial drug resistance.
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Scanning electron micrograph of MRSA interacting with a neutrophil
Infection

Vancomycin derivatives overcome multidrug resistance in S. aureus

Aug. 8, 2024
Researchers at Leiden University have synthesized semisynthetic guanidino lipoglycopeptides with in vitro and in vivo activity gram-positive bacteria, including methicillin-resistant and vancomycin-resistant Staphylococcus aureus.
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Dermatologic

ATR04-484 prevents EGFR inhibitor-associated skin toxicity

May 31, 2024
Several cancer types are treated with epidermal growth factor receptor (EGFR)-targeting agents (EGFR inhibitors), but this treatment is associated with dermal toxicity in up to 90% of cases, where 80% of cases have rash, among other issues. This skin toxicity is mainly driven by elevation of Staphylococcus aureus and the proinflammatory cytokine IL-36γ. Skin keratinocytes’ cutaneous immune defense is impaired by EGFR inhibitors.
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Immune

Evaxion’s EVX-B1 vaccine antigens reduce S. aureus bacterial burden in surgical site infection model

April 3, 2024
Evaxion Biotech A/S and a collaborator have successfully concluded a series of large nonrodent animal infection studies testing antigens from Evaxion’s preclinical EVX-B1 vaccine candidate against Staphylococcus aureus. The EVX-B1 antigens were shown to significantly reduce disease burden.
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Digital handshake

Merus, Gilead ink $1.5B+ deal; Biomx merges with Adaptive Phage

March 6, 2024
By Jennifer Boggs
Merus NV added Gilead Sciences Inc. to its collaboration roster, entering a deal potentially worth more than $1.5 billion. While its previous agreements have focused primarily on bispecific antibodies, the Gilead alliance takes aim at trispecifics, antibodies capable of binding three targets at once. In other news, shares of Biomx Inc. (NYSE:PHGE) jumped 194% March 6, ending the day at 68 cents, up 45 cents, on news that it was merging with fellow phage-focused company Adaptive Phage Therapeutics Inc. and raised $50 million in a concurrent private placement.
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Infection

Ohio State University divulges new bacterial topoisomerase inhibitors for S. aureus infections

Feb. 15, 2024
Ohio State University has synthesized DNA topoisomerase II (bacterial) inhibitors reported to be useful for the treatment of Staphylococcus aureus infections.
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More Articles Tagged with 'Staphylococcus aureus'

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