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Home » Keywords » microbiota

Items Tagged with 'microbiota'

ARTICLES

Illustration representing connection between brain and gut microbiome.
Neurology/psychiatric

CJRB-302 restores gut microbiota, improves motor symptoms, and prevents neurodegeneration in PD

April 17, 2025
At the 2025 International Conference on Alzheimer’s and Parkinson’s Diseases and Related Neurological Disorders (ADPD), researchers from Rutgers University investigated the therapeutic potential of CJRB-302, a live biotherapeutic product derived from healthy human gut microbiota, to improve PD motor symptoms and pathology.
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Hands holding holographic intestine
Substance use & poisoning

Glycopolymer radiomitigator protects mice from radiation-induced GI injury

March 6, 2025
Exposure to high-dose radiation can result in gastrointestinal (GI) acute radiation syndrome, which is characterized by disruption of the mucosal layer, intestinal epithelial barrier dysfunction, and abnormal inflammatory responses. Currently, there are no FDA-approved therapies for the treatment radiation-induced GI injury.
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Lab sample and bone marrow illustration
Immune

Intestinal microbiota have a say in graft-vs-host disease

July 24, 2023
By Mar de Miguel
Avoidance of graft-vs.-host disease (GVHD) after a hematopoietic stem cell transplant could depend on certain members of the microbiome. According to a study led by scientists at the Fred Hutchinson Cancer Center (FHCC), while some species of intestinal bacteria repressed the expression of the major histocompatibility complex II (MHC-II), others induced it and triggered the immune response that produces GVHD.
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Villi in intestinal tract.
Gastrointestinal

EASL 2023: Microbiota, intestinal permeability play roles in gut-liver crosstalk

June 22, 2023
By Coia Dulsat
During the first talk of the Basic Science Seminar sessions at the 2023 EASL International Liver Congress, focusing on the gut-liver axis, Prof. Maria Rescigno from Humanitas University presented data on the interaction between the gut and the liver and the role of microbiota and intestinal permeability in health and disease.
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Layoff illustration

Finch drops phase III of CP-101 for C. difficile, reduces staff by 95%

Jan. 24, 2023
By Karen Carey
Microbiome company Finch Therapeutics Group Inc. has suffered one blow after another in the past year with dwindling cash, delayed programs, a terminated deal and three workforce reductions. The latest reduction will bring the once healthy 189-person company down to a handful of employees, and it places the lead program – the oral microbiota product, CP-101, for Clostridium difficile infection – on the sidelines.
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Cancer cells under magnifying glass

Researchers in China find evidence in mice that bacteria in tumors help cancer cells metastasize

April 8, 2022
By Tamra Sami
Researchers in China have discovered that bacteria promote cancer metastasis by bolstering the strength of host cells against mechanical stress in the bloodstream, promoting cell survival during tumor progression.
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Guts, glory: 'Seres' of tries in microbiome may yield success yet, experts insist

Sep. 13, 2019
By Randy Osborne
BOSTON – The gut microbiome and its prospects for drug development have been matters of debate for a while, sharpened by the high-profile phase II failure of Seres Therapeutics Inc.'s candidate, SER-109, in the summer of 2016. A panel at Biopharm America surveyed the space in light of developments since the stumble with that candidate, composed of about 50 species of firmicutes spores derived from stool specimens from healthy donors, against recurrent Clostridium difficile infection. 
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