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Home » Keywords » APOE

Items Tagged with 'APOE'

ARTICLES

Gold dollar sign

Samsung life science fund invests $10M in C2N Diagnostics

March 14, 2025
By Marian (YoonJee) Chu
Samsung Life Science Fund made its first strategic investment of the year into C2N Diagnostics LLC, underscoring the rising potential of blood-based diagnostics in detecting and monitoring the risk of Alzheimer’s disease for the masses.
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Elderly hands holding broken brain structure
Neurology/psychiatric

Switch Therapeutics nominates liver-sparing APOE RNAi therapy as development candidate for Alzheimer’s

Dec. 4, 2024
Switch Therapeutics Inc. has announced its first development candidate, a liver-sparing APOE (apolipoprotein E) RNAi therapy for treatment of Alzheimer’s disease in APOE4 carriers. Switch’s conditionally activated siRNA (CASi)-APOE program is designed to knock down APOE in the CNS without affecting APOE in the liver, where it plays a vital role in systemic lipid homeostasis.
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Silhouette of head and brain with DNA double helixes
Neurology/psychiatric

Two copies of APOE4 cause genetic form of Alzheimer’s

May 6, 2024
By Anette Breindl
Based on its analysis of a large cohort of individuals homozygous for the ε4 variant of apolipoprotein E (APOE4), a multinational team of researchers is arguing that homozygosity for APOE4 should be considered a genetic form of Alzheimer’s disease. However, not everyone agrees that the findings warrant reclassifying APOE from risk factor to causal gene. Currently, APOE4 is classified as the strongest risk factor for developing AD. Another variant, the APOE2 variant, is protective, while APOE3 is neutral.
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Neurology/psychiatric

Two copies of ApoE4 cause genetic form of Alzheimer’s

May 6, 2024
By Anette Breindl
Based on its analysis of a large cohort of individuals homozygous for the ε4 variant of apolipoprotein E (ApoE4), a multinational team of researchers is arguing that homozygosity for ApoE4 should be considered a genetic form of Alzheimer’s disease (AD).
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DNA double helix made up of a spoon and fork
Genetic/Congenital

Machine learning sleuthing yields undiagnosed binge eating patients, insights

Aug. 16, 2023
By Anette Breindl
By using machine learning techniques to scour electronic health records, researchers have identified individuals who were likely to have binge eating disorder (BED) but had not received a formal diagnosis. Genomewide association studies including such patients enabled the investigators to identify several risk variants that were correlated with BED irrespective of body mass index (BMI), which covaries with BED and is a potential confounding factor.
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PET imaging of RELN-COLBOS (H3447R) carrier brain showing limited aggregation of tau
Neurology/Psychiatric

Reelin’ in druggable protective pathways with second Alzheimer’s ‘escapee’

May 15, 2023
By Anette Breindl
Investigators have identified a second individual who remained cognitively normal into his late 60s despite having the PSEN1 E280A mutation, which causes a familial version of early-onset Alzheimer’s disease (AD). The likely source of protection, a mutation in a gene called Reelin, is distinct from the protective mechanism identified in the first case of an individual who was protected from the effects of PSEN1 E280A. That case was reported in 2019.
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3D illustration showing tumor inside prostate gland and closeup view of cancer cells
Biomarkers

Altered plasma proteins tied to progression in castration-resistant prostate cancer

Jan. 27, 2023
Androgen deprivation therapy (ADT) is still the main treatment option for locally advanced and metastatic prostate cancer (PCa); however, most patients receiving ADT develop resistance to treatment and relapse, with a more aggressive form of cancer, castration-resistant prostate cancer (CRPC).
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Coronavirus and DNA
Biomarkers

APOE gene impacts survival in COVID-19 disease

Oct. 10, 2022
The factors why the clinical outcomes during infection with SARS-CoV-2 virus are highly heterogenous remains poorly understood. Apolipoprotein E (APOE) is a secreted protein with roles in lipid metabolism; interestingly, APOE has been shown to modulate immunity, including infection and antitumor immunity.
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Elderly hands holding broken brain structure

Rare APOE variant gives insight into Alzheimer's pathogenesis

Oct. 8, 2021
By W. Todd Penberthy
Despite the identification of the APOE gene as the strongest genetic link to late-onset Alzheimer's disease (AD) since 1993 and the subsequent advances in the understanding of AD pathogenesis, the development of effective consensus-directed treatment therapies has yet to be realized.
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Tau neuron illustration

LDL receptor overexpression affects tauopathy in Alzheimer's model

June 29, 2021
By W. Todd Penberthy
Researchers report in the June 21, 2021, online issue of Neuron that overexpression of the LDL receptor can reduce ApoE to prevent tauopathy-associated neurodegeneration in mouse models.
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