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Home » Keywords » UK Biobank

Items Tagged with 'UK Biobank'

ARTICLES

Blood samples in lab
Drug design, drug delivery & technologies

Proteomics study explores how protein changes influence disease

Jan. 13, 2025
By Nuala Moran
Fourteen global pharma companies are getting together to conduct the largest proteomics study to date, analyzing 600,000 blood samples held in the UK Biobank to assess the levels of 5,400 different proteins.
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Blood samples in lab

Proteomics study explores how protein changes influence disease

Jan. 10, 2025
By Nuala Moran
Fourteen global pharma companies are getting together to conduct the largest proteomics study to date, analyzing 600,000 blood samples held in the UK Biobank to assess the levels of 5,400 different proteins.
Read More
DNA illustration
Drug design, drug delivery & technologies

Oxford Nanopore Technologies and UK Biobank collaborate to create epigenetic dataset

Nov. 27, 2024
Oxford Nanopore Technologies Ltd. has established a new collaboration with UK Biobank to create the world’s first comprehensive, large-scale epigenetic dataset. The project will utilize Oxford Nanopore’s DNA/RNA sequencing technology to map the epigenome of 50,000 blood samples from UK Biobank to unlock insights into disease mechanisms, with the aim of improving patient outcomes.
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Illustration of retinal detachment
Biomarkers

VSX2 variant linked to retinal detachment risk

Nov. 19, 2024
Researchers from the U.K. have analyzed whole-genome sequencing data from 7,276 cases and 236,741 controls in the UK Biobank to perform gene-level and a variant-level exome-wide association study analysis to identify variants related to retinal detachment.
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Female doctor with 3D medical model of pelvis
Genitourinary/sexual function

Neuregulin variant predicts gabapentin efficacy in chronic pelvic pain

July 31, 2024
Investigators at the University of Edinburgh have identified a genomic location linked to sensitivity to gabapentin in individuals with idiopathic chronic pelvic pain.
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DNA NGS genome sequencing

A Google Maps for genomics: UK Biobank opens access to 15 years of genome sequencing data

Nov. 30, 2023
By Nuala Moran
After five years and 350,000 hours of DNA sequencing, the UK Biobank has opened up access Nov. 30 to the whole genome sequences of half a million people who volunteered to give samples 15 years ago.
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Illustration of COVID-19 virus cells affecting brain

Matching scans show COVID-19 effects on brain

March 9, 2022
By Nuala Moran
An analysis of brain scans of participants in the UK Biobank has shown there are significant differences between the condition of the brain before and after mild COVID-19 infection. These included a reduction in overall brain size, reduction in grey matter thickness in the orbitofrontal cortex and hippocampal gyrus, and changes in markers of tissue damage in regions functionally connected to the primary olfactory cortex. Infected participants also showed, on average, a larger cognitive decline than participants who had not contracted COVID-19.
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Silhouette made of crumpled paper illustrating depression

Inflammation, depression share "core biological process"

June 1, 2021
By Nuala Moran
While there is known to be an association between inflammation and depression, it is not known if there is cause and effect. Now, the power of the UK Biobank has been brought to bear to show that when all genetic, health and environmental factors are accounted for, people with depression have higher levels of inflammation in their bodies than controls.
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Disease architecture of the sepsis cohort generated by the Precisionlife platform

Precisionlife identifies 59 compounds based on assessment of sepsis risk genes in severe COVID-19

May 6, 2020
By Nuala Moran
LONDON – Computational biology specialist Precisionlife Ltd. has used UK Biobank data to find sepsis risk genes that are present specifically in patients who suffer severe COVID-19 infections and shown that 13 of those genes are known druggable targets.
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DNA illustration
APOE has secrets left

Large datasets, good statistics allow disease-agnostic SNP discoveries

Dec. 24, 2019
By Nuala Moran
LONDON – While large-scale biobanks that link genomics to longitudinal health records of diagnosis, treatment and outcomes promise to revolutionize the understanding of the genetics of complex disease, the detailed statistical analysis of those high-dimensional data is still very much in its infancy.
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