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Home » Keywords » T cells

Items Tagged with 'T cells'

ARTICLES

3D illustration of T cells fighting cancer
Cancer

Modified viral protein boosts T cell power via STAT5

May 27, 2025
By Coia Dulsat
No Comments
Researchers at the University of Michigan designed an optimized viral protein able to boost the antitumor function of T cells. The project stemmed from observations on the particular system employed by Herpesvirus saimiri to infect T cells and hijack cellular pathways by activating them.
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Tilt’s $25.6M series B advances TILT-123 for ovarian cancer

May 13, 2025
By Nuala Moran
No Comments
Tilt Biotherapeutics Ltd. has raised $25.6 million in a series B round that will fund phase II development of the lead oncolytic virus in the treatment of platinum-resistant ovarian cancer.
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Newco news

Hillstar launches with $67M series A to target TRBV9+ T cells

March 25, 2025
By Brian Orelli
Hillstar Bio came out of stealth mode, announcing a $67 million series A financing round with investors including Droia Ventures, Frazier Life Sciences, Novo Holdings A/S and Lifearc Ventures.
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Amgen’s rocatinlimab data underwhelm in atopic dermatitis trial

Sep. 25, 2024
By Jennifer Boggs
As Eli Lilly and Co. launches its recently approved Ebglyss (lebrikizumab) in an atopic dermatitis market already dominated by established biologic Dupixent (dupilumab, Regeneron Pharmaceuticals Inc.), investors tuned into an Amgen Inc. investor call disclosing positive top-line phase III results for rocatinlimab, a monoclonal antibody that could potentially offer patients a new mechanism of action. While data from the Rocket Horizon study showed rocatinlimab hit all co-primary and secondary endpoints, the early findings fell below expectations in a highly competitive market.
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Cancer cells under magnifying glass
Cancer

ESMO 2024: For T-cell target antigens, lots to see, but what to show?

Sep. 16, 2024
By Anette Breindl
Metastatic solid tumors may be curable now. Among the most profound results presented over the weekend at the European Society for Medical Oncology (ESMO) 2024 Congress were the 10-year data from the Checkmate-067 and Keynote-006 trials, the phase III trials that tested Opdivo (nivolumab, Bristol Myers Squibb Co.) and Keytruda (pembrolizumab, Merck & Co. Inc.) as first-line agents in advanced or metastatic melanoma.
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Adenovirus cells
Immuno-oncology

Vironexis exits stealth with 10+ AAV-delivered immuno-oncology candidates

Sep. 13, 2024
By Brian Orelli
Vironexis Biotherapeutics Inc. has come out of stealth mode, disclosing that it has more than 10 product candidates it’s been developing over the last three years. The therapies are built on the company’s AAV-based platform, Transjoin, which is designed to have patients' livers express bispecific antibodies that bind to both CD3 on T-cells and various targets on tumor cells.
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Adenovirus cells
Newco news

Vironexis exits stealth with 10+ AAV-delivered immuno-oncology candidates

Sep. 12, 2024
By Brian Orelli
Vironexis Biotherapeutics Inc. came out of stealth mode today, disclosing that it has more than 10 product candidates it’s been developing over the last three years. The therapies are built on the company’s AAV-based platform, Transjoin, which is designed to have patients' livers express bispecific antibodies that bind to both CD3 on T-cells and various targets on tumor cells.
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T cells
Neurology/psychiatric

Autoimmune T cells may be beneficial for CNS injuries

Sep. 11, 2024
By Xavier Bofill Bruna
Immunotherapy based on T cells is the vanguard of cancer treatments. Researchers from Washington University in St. Louis have shown that similar approaches using T cells could be applied for treating injuries of the central nervous system (CNS). They reported their findings in Nature on Sept. 4, 2024.
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T cells
Neurology/psychiatric

Autoimmune T cells may be beneficial for CNS injuries

Sep. 9, 2024
By Xavier Bofill Bruna
Immunotherapy based on T cells is the vanguard of cancer treatments. Researchers from Washington University in St. Louis have shown that similar approaches using T cells could be applied for treating injuries of the central nervous system (CNS). They reported their findings in Nature on Sept. 4, 2024.
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Immatics nails melanoma phase I; Iovance, Immunocore busy, too

May 14, 2024
By Randy Osborne
Immatics NV’s IMA-203 “looks like a melanoma drug,” said Cantor Fitzgerald analyst Eric Schmidt after he took a peek at the latest data, prepared as part of an upcoming meeting with the U.S. FDA. The candidate emerged from Immatics’ Actengine platform, set up to formulate a personalized therapy in which a patient’s own T cells are collected, genetically modified and then reinfused. Immatics offered data with IMA-203 as a monotherapy that targets preferentially expressed antigen in melanoma from an ongoing phase I trial testing what’s been established as the recommended phase II dose of 1-10x109 TCR-T cells in 30 heavily pretreated metastatic melanoma patients who were evaluable for efficacy.
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