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Home » Keywords » cytokine

Items Tagged with 'cytokine'

ARTICLES

Cancer cells being destroyed by immunotherapy

Xilio inks $648M IL-12 deal with Gilead, reprioritizes pipeline

March 28, 2024
By Karen Carey
Xilio Therapeutics Inc. retreated with its lead oncology IL-2 drug, XTX-202, after phase II data indicated stable disease was the best response, prompting the company to reprioritize its pipeline and cut its workforce by 21% – but investors focused more on a $647.5 million IL-12 program deal the company signed with Gilead Sciences Inc., as well as an $11.3 million private placement financing.
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Macrophage releasing cytokines as a part of the body's immune response.
Newco news

Not just another cytokine? Simcha looks to rejuvenate IL-18 field with decoy resistance

Sep. 20, 2023
By Caroline Richards
Although preclinical studies of genetically engineered interleukin-18 (IL-18) historically indicated its potential in cancer treatment, interest in the cytokine languished after GSK plc shelved its IL-18 therapeutic on lack of responses in a phase II melanoma trial. But in 2020, Yale University-based professor of immunobiology Aaron Ring set about reviving IL-18 as a cancer therapeutic. He went on to engineer a decoy-resistant form of IL-18 and then founded Simcha Therapeutics Inc. to develop the drug – named ST-067.
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Avalo falls on trial miss, but company sees positive LIGHT

June 26, 2023
By Jennifer Boggs
While investors focused on the top-line miss from Avalo Therapeutics Inc.’s phase II study of AVTX-002 (quisovalimab) in non-eosinophilic asthma, sending company shares (NASDAQ:AVTX) falling 89% to close at 50 cents June 26, the company pointed to promising trends seen in an exploratory analysis affirming the potential of targeting LIGHT.
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Hands holding gears

Bonum to continue Good work after $250M cash acquisition deal with Roche

Sep. 7, 2022
By Jennifer Boggs
For privately held Good Therapeutics Inc., founded in 2016 with a platform technology for developing context-dependent therapeutics, the plan had always been to seek a buyer for the first asset to emerge. One came along a little earlier than expected, as Roche Holding AG entered a merger agreement for Good, picking up preclinical-stage PD-1-regulated IL-2 program, in exchange for an up-front cash payment of $250 million.
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3D illustration of heart cross section

Cytokine promotes heart repair after infarct

June 20, 2022
By Anette Breindl
Researchers at Hannover Medical School have gained new insights into the cytokine meteorin-like (METRNL) and its role in promoting heart repair after myocardial infarction.
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Antibodies attacking cancer cell

Askgene’s series A adds $20M for cytokine fusion, antibody pipeline

May 10, 2022
By Jennifer Boggs
Askgene Pharma Inc., which less than two weeks ago reported positive initial data from an ongoing phase I/II trial testing its claudin 18.2-targeting candidate, ASKB-589, added $20 million in a series A round, intended to advance the company’s clinical pipeline and support further development of its Smartkine cytokine drug platform.
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Antibodies attacking cancer cell

Askgene’s series A adds $20M for cytokine fusion, antibody pipeline

May 9, 2022
By Jennifer Boggs
Askgene Pharma Inc., which less than two weeks ago reported positive initial data from an ongoing phase I/II trial testing its claudin 18.2-targeting candidate, ASKB-589, added $20 million in a series A round, intended to advance the company’s clinical pipeline and support further development of its Smartkine cytokine drug platform.
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Grey dollar sign on grey background

Ankyra Therapeutics raises $45M series B to advance cytokine immunotherapies

Nov. 15, 2021
By Michael Fitzhugh
Ankyra Therapeutics Inc., a company developing new cytokine immunotherapies to boost localized antitumor immune responses, closed a $45 million series B financing. Proceeds from the round will be used to advance the Boston-based company's lead molecule, ANK-101, through IND-enabling studies and into phase I trials starting at the beginning of 2023, as well as to advance additional cytokine programs, it said.
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Biotech deal illustration

Merck & Co. inks possible $1B R&D deal with Synthekine as Acceleron merger hits speed bump

Nov. 1, 2021
By Richard Staines
Merck & Co. Inc. has signed a potential $1 billion research tie-up with Synthekine Inc. to develop engineered cytokines to fight autoimmune diseases, as its $11.5 billion merger with Acceleron Pharma Inc. hit a regulatory speed bump.
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Cancer cells under magnifying glass

Cytokine-induced JAK/STAT signaling plays role in cachexia

Aug. 23, 2021
By Subhasree Nag
A multidisciplinary team of researchers has identified Upd3, a cytokine, as an important modulator of tumor growth and host wasting via activation of JAK/STAT signaling.
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More Articles Tagged with 'cytokine'

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