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Home » Keywords » HCC

Items Tagged with 'HCC'

ARTICLES

Immuno-oncology

Targeting BPTF boosts NK cell immunotherapy in liver cancer

Feb. 25, 2025
Enhanced quantity and functionality of natural killer (NK) cells in hepatocellular carcinoma (HCC) have been associated with improved prognosis and survival. Therefore, NK cell-based immunotherapy has been proposed for treating HCC, relying on the activation of NK cell receptors like natural cytotoxicity receptors (NCRs), which recognize specific ligands on HCC cells. However, the effectiveness of this approach remains low due to tumor immune evasion.
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Doctor pointing at liver
Cancer

Mouse model studies provide proof of concept for Sunshine Biopharma’s K1.1 mRNA product for HCC

Dec. 3, 2024
Sunshine Biopharma Inc. has completed mouse model studies providing proof of concept for the company’s K1.1 mRNA product as a novel therapeutic agent for human hepatocellular carcinoma (HCC).
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Liver tumor treatment conceptual illustration
Biomarkers

RAC1 has prognostic value in hepatocellular carcinoma

Sep. 26, 2024
Hepatocellular carcinoma (HCC) has a poor prognosis due to late diagnosis and lack of effective therapies.
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Liver tumor treatment conceptual illustration
Biomarkers

Role of UBXN1-PHB interaction in mitochondrial homeostasis and liver tumorigenesis

May 30, 2024
The maintenance of mitochondrial homeostasis plays a crucial role in tumor cell survival and growth. Mitochondrial integrity is regulated by proteins in the mitochondrial inner membrane, such as prohibitin (PHB). PHB has been found overexpressed in several cancer types and contributes to tumorigenesis.
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Cancer

DNMT3L overexpression abrogates HCC proliferation, study unveils

Feb. 6, 2024
Hepatocellular carcinoma (HCC) remains among the most aggressive tumor types and its early diagnosis is still a challenge.
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Immuno-oncology

Targeting RNase1 reduces resistance to anti-PD-1 immunotherapy in HCC

Feb. 6, 2024
Researchers from Sun Yat-Sen University and MD Anderson Cancer Center have compared the proteins secreted by hepatocellular carcinoma (HCC) cells in responders and nonresponders to the anti-PD-1 antibody nivolumab.
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Cancer

In vivo XPO1 inhibition induces HCC tumor regression in mice

Feb. 5, 2024
Myc proto-oncogene protein (MYC) is a transcription factor that can modulate the transcription of several genes, and its overexpression has been found in many cancer types, including hepatocellular carcinoma (HCC). Its inhibition reverses tumorigenesis in vivo and it is a key therapeutic target in cancer. Stanford University scientists used CRISPR screening assays to identify several genes as downstream targets of MYC, including exportin-1 (XPO1), among others.
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Jin Yanggon, chairman, HLB

KIW 2023: ‘HLB ready to take 50% of liver cancer market with rivoceranib’

Sep. 12, 2023
By Marian (YoonJee) Chu
HLB Co. Ltd. is ready to take half of the liver cancer treatment market with its potential first-line treatment, rivoceranib, currently undergoing U.S. FDA review, company chairman Jin Yang-gon said, backed by positive survival data that beat out competitors by three months.
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Cancer

Novel splice switching oligonucleotide for hepatocellular carcinoma

July 6, 2023
Hepatocellular carcinoma (HCC) is the most frequent tumor of the liver, and in contrast to the reduction in the number of deaths in many common cancers, HCC’s mortality rates have gone up in recent years. One of the features that characterizes HCC is the activation of the Wnt/β-catenin signaling. Recent preclinical testing in HCC models has shown a reduction in tumor growth using siRNA or ASOs acting as β-catenin inhibitors.
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Liver illustration
Gastrointestinal

EASL 2023: Insights on bidirectional crosstalk in the liver-brain axis

June 23, 2023
By Coia Dulsat
While the liver is mostly known as the core of metabolism, contributing to the storage of nutrients and excretion of toxic substances, there is an increasing interest in how it interacts with the central nervous system through the liver-brain axis. At the 2023 European Association for the Study of the Liver (EASL) meeting in Vienna, Austria, group leader Kristina Schoonjans and her colleague Hadrien Demagny from the Laboratory of Metabolic Signaling at École Polytechnique Fédérale de Lausanne, Switzerland, gave talks setting out the context of inter-organ communication in liver disease, adding new findings from their research in the liver-brain axis.
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