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Home » Keywords » hematopoietic stem cells

Items Tagged with 'hematopoietic stem cells'

ARTICLES

Blood cells and destruction of cancer cell
Cancer

A pan-approach against blood cancer preserving hematopoiesis

May 29, 2024
By Mar de Miguel
A group of scientists from Basel University Hospital have designed an antibody-drug conjugate (ADC) that eliminated blood cancer cells without attacking healthy hematopoietic stem cells (HSCs), which they modified by base editing and transplanted to renew an altered blood system. They achieved this by focusing on the panhematopoietic marker CD45.
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Silhouette of child and brain

Orchard-Kyowa scores US approval for gene therapy Lenmeldy

March 18, 2024
By Marian (YoonJee) Chu
The U.S. FDA approved Orchard Therapeutics plc’s BLA for gene therapy atidarsagene autotemcel, making it the first treatment option for metachromatic leukodystrophy in the U.S. The one-time treatment, branded Lenmeldy, is indicated for children with presymptomatic late infantile, presymptomatic early juvenile or early symptomatic early juvenile disease.
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Cells, DNA illustration
Immuno-oncology

Epitope editing in hematopoietic cells provides CAR T immunotherapy against all types of blood cancer

Sep. 22, 2023
A new method of CAR T-cell immunotherapy developed by researchers at the University of Pennsylvania Perelman School of Medicine could serve as a treatment for most blood cancers. Until now, CAR T-based immunotherapy for hematological malignancies has targeted the antigens CD19 for B cells, CD7 for T cells, BCMA for myeloma, and CD33 for AML.
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Fluorescence microscopy image of mitochondria
Hematologic

Mitochondrial modulator rejuvenates blood stem cells

Sep. 4, 2023
By Nuala Moran
Researchers have demonstrated that inhibiting mitophagy in ‘old’ hematopoietic stem cells (HSCs) completely restored their blood reconstitution capabilities, raising the prospect of addressing the age-related weakening of the immune system that stems from HSCs deteriorating over time.
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3D illustration of the Anakinra molecular structure
Hematologic

Edited blood stem cells dampen disordered inflammation

June 8, 2023
By Anette Breindl
Researchers have ameliorated both monogenic and complex inflammation-driven diseases through transplantation of hematopoietic stem cells with an inserted IL-1 receptor antagonist (IL-1RA) gene. The team showed that in animal models the transplanted cells worked better than monoclonal antibodies to reduce symptoms in systemic autoinflammatory diseases (SAIDs), a group of childhood-onset, lifelong diseases that vary in severity depending on the underlying mutation, but can be life-threatening.
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Sickle cell illustration
Hematologic

Ex vivo prime editing could reverse sickle cell disease

May 3, 2023
A proof of concept of ex vivo genetic modification of cells from patients and their transplantation in mice has demonstrated, for the first time, the therapeutic possibilities of prime editing in sickle cell disease (SCD).
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Illustration of pencil erasing DNA helix
Immune

Stem cell base editing restores T cells in severe combined immunodeficiencies

March 27, 2023
By Mar de Miguel
Base editing (BE), a technique that modifies a single nucleotide in living cells, has been successfully tested to resolve the CD3δ mutation in severe combined immunodeficiencies (SCIDs) and produce functional T cells. For now, scientists at the University of California, Los Angeles (UCLA), completed the study on patient stem cells and artificial thymic organoids, shortening the way for future clinical trials.
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Fly like an eagle: Garuda brings in a $62M series B

Feb. 7, 2023
By Lee Landenberger
The science that led Garuda Therapeutics Inc. to a $62 million series B financing was a combination of hard work, luck and serendipity, according to co-founder and CEO Dhvanit Shah. At the Harvard Stem Cell Institute, Shah and his fellow researchers found that endothelial cells go through significant modifications before becoming hematopoietic stem cells. That simple discovery, as Shah told BioWorld, brought on research leading to the possibility that patients would not need a marrow donor before receiving a stem cell treatment.
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Stem cells
Newco news

Juvena looking to hESC-secreted proteins for treating age-related disease

Jan. 11, 2023
By Jennifer Boggs
Juvena Therapeutics Inc. co-founder and CEO Hanadie Yousef had the company’s name picked out several years before it was officially incorporated in 2017 to combine Yousef’s work in the mechanics of aging with an underutilized class of biologics and an advanced proteomics platform to tackle chronic and age-related diseases.
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Red blood cells

Long in the making changes lead to tipping point in blood stem cells

June 3, 2022
By Nuala Moran
Two studies published back to back in Nature have looked at the accumulation of mutations in blood-forming stem cells with age, gaining new insights into how the overall landscape of such cells changes across the lifespan. 
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