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Home » Keywords » inteins

Items Tagged with 'inteins'

ARTICLES

Gold dollar sign

Series B brings Splicebio $135M for Stargardt disease asset

June 11, 2025
By Nuala Moran
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Three months after dosing the first patient with its dual vector gene therapy, Splicebio SL has closed a $135 million series B to fund the phase I/II trial of SB-007 in the treatment of Stargardt’s disease to completion. Other adeno-associated viru gene therapies for the inherited retinal disorder have entered the clinic, but SB-007 is the first with the capacity to deliver a full version of the ABCA4 gene that underlies Stargardt’s.
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Splicebio raises record series A to tackle AAV packing problem

Feb. 16, 2022
By Nuala Moran
LONDON – In the largest-ever series A for a Spanish biotech, Splicebio S.L. has raised €50 million (US$56.9 million) to apply its protein splicing technology to the delivery of large genes that do not fit into existing vectors. The company claims its approach will overcome the capacity constraints of adeno-associated viral vectors (AAVs), by splitting genes into parcels and reconstituting the proteins they express in vivo.
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Gloved hand holding petri dish in lab

Protein introns, "inteins", are antifungal targets

Jan. 5, 2021
By Anette Breindl
Researchers from the State University of New York at Albany have identified small molecules that could inhibit intein self-splicing from the protein PrP8 in the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii, emerging pathogens that can cause fungal meningitis in immunocompromised patients.
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