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Home » Keywords » microRNA

Items Tagged with 'microRNA'

ARTICLES

Regulus’ rare kidney disease drug draws Novartis in potential $1.7B buyout

April 30, 2025
By Jennifer Boggs
Regulus Therapeutics Inc. CEO Jay Hagan told investors in a January call the company had no interest in “simply out-licensing” rights to lead candidate farabursen, an oligonucleotide targeting autosomal dominant polycystic kidney disease set to start phase III testing on a path to a potential accelerated approval. And now, there’s no need to, as Regulus found a buyer for the whole company in a deal with Novartis AG valued at about $1.7 billion.
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Illustration of polycystic kidney

Regulus heads to phase III after more positive kidney disease data

Jan. 29, 2025
By Jennifer Boggs
In an indication that has proved difficult for biopharma to conquer, Regulus Therapeutics Inc. disclosed further positive data from its ongoing phase Ib study testing RGLS-8429 in autosomal dominant polycystic kidney disease and laid out its plans to move straight into a phase III trial later this year, with the potential for an accelerated U.S. approval.
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COVID-19 research illustration
Biomarkers

miR-1-3p levels predict case severity in hospitalized COVID-19 patients

Dec. 13, 2024

Increasing evidence shows that circulating microRNAs (miRNAs) regulate biological processes involved in COVID-19 complications.


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COVID-19 research illustration
Biomarkers

miR-1-3p levels predict case severity in hospitalized COVID-19 patients

Dec. 10, 2024

Increasing evidence shows that circulating microRNAs (miRNAs) regulate biological processes involved in COVID-19 complications.


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Illustration of glucose molecules in a bloodstream
Cardiovascular

miR-210 behind diabetes-induced endothelial dysfunction

Oct. 21, 2024
Cardiovascular disease is among the leading causes of death in individuals with type 2 diabetes. The role that microRNA 210 (miR-210) plays in endothelial cells and in diabetes-driven endothelial dysfunction is not clearly understood. Its potential as a therapeutic target was investigated.
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Cancer

LiPBAE miR-590-3p nanomiR extends survival in mice with GBM

Oct. 17, 2024
Glioblastoma multiforme (GBM) recurs in most patients despite the aggressive therapies they receive. Novel advances allow the development of targeted therapies to treat tumors of the brain. Researchers from the Johns Hopkins School of Medicine have applied bioinformatics plus forward thinking on microRNA biology to advance targeted therapies for GBM.
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Illustration of Victor Ambros and Gary Ruvkun
Biomarkers

Two win Nobel for microRNA work

Oct. 8, 2024
By Mar de Miguel
Research into the regulation of gene expression experienced a significant breakthrough with the discovery of microRNA, small RNA molecules that do not code for proteins but control their translation. This finding has earned its discoverers – Victor Ambros and Gary Ruvkun – the 2024 Nobel Prize in Physiology or Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation.”
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Biomarkers

Nobel Prize in Physiology or Medicine for discovering microRNA

Oct. 7, 2024
By Mar de Miguel
Research into the regulation of gene expression experienced a significant breakthrough with the discovery of microRNA, small RNA molecules that do not code for proteins but control their translation. This finding has earned its authors Victor Ambros and Gary Ruvkun the 2024 Nobel Prize in Physiology or Medicine.
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Illustration of Victor Ambros and Gary Ruvkun
Biomarkers

Two win Nobel for microRNA work

Oct. 7, 2024
By Mar de Miguel
Research into the regulation of gene expression experienced a significant breakthrough with the discovery of microRNA, small RNA molecules that do not code for proteins but control their translation. This finding has earned its discoverers – Victor Ambros and Gary Ruvkun – the 2024 Nobel Prize in Physiology or Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation.”
Read More
AI-generated illustration of muscular man running

ARDD 2024: Age without disease, exercise muscles and win $111M

Sep. 3, 2024
By Mar de Miguel
Aging is part of the life cycle and, although the effects are not manifest until after adulthood, it actually occurs from birth. The concept of senescence has traditionally been associated with aging. However, an embryo has senescent cells. In that case, what is aging, how can it be measured, and from what point in the life cycle?
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More Articles Tagged with 'microRNA'

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