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Home » Keywords » neuroblastoma

Items Tagged with 'neuroblastoma'

ARTICLES

Real fluorescence microscopic view of human neuroblastoma cells
Cancer

CID-078 exhibits robust antitumor efficacy in preclinical neuroblastoma models

May 28, 2025
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Neuroblastoma is a pediatric solid tumor characterized by dysregulation of the CDK-RB-E2F axis, leading to elevated E2F activity, uncontrolled progression through the G1/S transition and an aggressive tumor phenotype. Researchers from Circle Pharma Inc. and collaborators presented preclinical data on CID-078, a first-in-class oral macrocycle with dual cyclin A and B RxL inhibitory activity, in models of neuroblastoma.
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Cancer

Combining KAT6A/B inhibitor and retinoic acid shows efficacy in neuroblastoma models

March 17, 2025
Neuroblastoma, an aggressive malignancy originating from neural crest cells, accounts for 15% of cancer-related deaths in children. Treatment strategies include systemic chemotherapy, radiation or immunotherapy with anti-GD2 antibodies, all with severe side effects and long-term toxicity. Retinoic acid (RA) has been shown to promote neuroblastoma growth inhibition while suppressing MYCN oncogene expression. However, its effect is reversible, and tumor regrowth may occur.
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Cancer

Chinese scientists describe new WDR5/c-Myc interaction inhibitors

Feb. 28, 2025
Researchers at Children’s Hospital of Fudan University, Shanghaitech University and Suzhou Zhongke New Drug Incubator Biomedical Technology Co. Ltd. have identified WD repeat-containing protein 5 (WDR5; BIG3)/c-Myc interaction inhibitors reported to be useful for the treatment of cancer.
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Cancer

CAIX inhibition could be approach to neuroblastoma treatment

Jan. 23, 2025
Neuroblastoma is the most common extracranial solid tumor in children and accounts for up to 15% of childhood cancer-related deaths worldwide. Neuroblastoma tumors are characterized by hypoxia, which represents a major challenge in its treatment.
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Immuno-oncology

DLK1-directed immunotherapy shows activity in neuroblastoma models

Dec. 10, 2024
Researchers from the Children's Hospital of Philadelphia presented data from a study that aimed to identify novel biologically relevant cell surface immunotherapeutic targets for neuroblastoma.
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Real fluorescence microscopic view of human neuroblastoma cells
Immuno-oncology

Invenra’s bispecific antibody awarded US orphan drug designation for neuroblastoma

Aug. 26, 2024
Invenra Inc.’s bispecific antibody, INV-724, developed for the treatment of neuroblastoma, has been awarded orphan drug and rare pediatric disease designations by the FDA.
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Real fluorescence microscopic view of human neuroblastoma cells
Cancer

Transcriptional co-repressor supports MYCN-driven neuroblastoma

Aug. 9, 2024
The interaction between the transcriptional co-repressor runt-related transcription factor 1 translocation partner 1 (Runx1t1) and MYCN, a member of the MYC proto-oncogene family, plays a crucial role in the development of neuroblastoma, according to a study led by the Children's Cancer Institute at Lowy Cancer Centre, UNSW Sydney.
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Acquisition target

Apeiron exits through M&A as Ligand gains Qarziba royalties

July 10, 2024
By Nuala Moran
Ligand Pharmaceuticals Inc. is adding one more income stream to its portfolio, with the $100 million acquisition of Apeiron Biologics AG, owner of royalty rights to Qarziba, a treatment for high risk neuroblastoma that is currently marketed in 35 countries and is en route to approval in the U.S.
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Antibodies attacking cancer cell
Immuno-oncology

Day One Biopharmaceuticals licenses PTK7-targeting ADC from Mabcare

June 19, 2024
Day One Biopharmaceuticals Inc. has entered into an exclusive licensing agreement with Mabcare Therapeutics for MTX-13, a novel antibody-drug conjugate (ADC) targeting protein-tyrosine kinase 7 (PTK7). Under the agreement, Day One has exclusive rights to develop, manufacture and commercialize MTX-13 (now DAY-301), worldwide, excluding Greater China.
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3D rendering of drug linked to antibody
Immuno-oncology

Merck KGaA advances anti-GD2 ADC toward clinic for solid tumors

June 4, 2024
Merck KGaA has announced it is advancing M-3554, a potential first-in-class anti-GD2 antibody-drug conjugate (ADC), toward the clinic. M-3554 links an exatecan payload with an anti-GD2 antibody.
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