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Home » Keywords » lipid nanoparticles

Items Tagged with 'lipid nanoparticles'

ARTICLES

3D pancreas illustration
Immuno-oncology

Platform tech reprograms immune responses against KRAS-mutant metastases

April 10, 2025
Pancreatic ductal adenocarcinom a (PDAC), frequently detected at advanced stages, has a 5-year survival rate of 12%. Metastases are common, including hepatic metastasis, which is particularly lethal due to the liver’s immune-tolerant environment and rich blood supply that facilitate tumor growth.
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Cholesterol plaque in artery
Cardiovascular

Epigenetic editing demonstrates long-lasting control of LDL-C levels in vivo by targeting PCSK9

March 3, 2025
Epigenetic editing is a promising method for gene regulation in vitro and in vivo, allowing precise control of gene expression without altering the DNA sequence, thereby minimizing genotoxic risks.
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Illustration of VEGF-A protein molecule
Women's health

Experimental mRNA gene therapy suppresses preeclampsia in mice

Dec. 17, 2024
By Mar de Miguel
A gene therapy based on an enhanced lipid nanoparticle (LNP) loaded with vascular endothelial growth factor (VEGF) mRNA could be developed for the treatment of preeclampsia, according to a study in mice in which it alleviated maternal hypertension until the end of gestation and improved fetal health. Preeclampsia is a disease that affects 3% to 5% of pregnant women, who suffer from hypertension and proteinuria, elevated levels of protein in the urine, during pregnancy.
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Infection

Preclinical characterization of Tune-401, a first-in-class LNP-encapsulated epigenetic silencer therapy for hepatitis B

Dec. 4, 2024
Tune Therapeutics Inc. is evaluating Tune-401.
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Vaccine vial and syringe
Infection

mRNA-1769 provides better protection against lethal mpox

Sep. 26, 2024
Researchers from Moderna Inc. and affiliated organizations presented preclinical data for the novel mRNA-lipid nanoparticle (LNP) vaccine, mRNA-1769, against mpox virus.
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mRNA on digital background
Newco news

Exsilio launches with $82M to develop mRNA-based gene therapies

July 2, 2024
By Brian Orelli
Exsilio Therapeutics emerged from stealth mode on June 25, 2024, with $82 million from a series A financing that was co-led by Novartis Venture Fund and Delos Capital. The company plans to use naturally occurring, mobile genetic elements to integrate therapeutic genes at a defined location in the genome, making it safer than random integration, which can cause tumor formation.
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mRNA on digital background
Newco news

Exsilio launches with $82M to develop mRNA-based gene therapies

June 25, 2024
By Brian Orelli
Exsilio Therapeutics emerged from stealth mode on June 25, 2024, with $82 million from a series A financing that was co-led by Novartis Venture Fund and Delos Capital. The company plans to use naturally occurring, mobile genetic elements to integrate therapeutic genes at a defined location in the genome, making it safer than random integration, which can cause tumor formation.
Read More
Hematologic

Optimized nonviral LNP system for hFVIII, P-FVIII-101, normalizes clotting efficacy in models of hemophilia A

May 22, 2024
Researchers from Poseida Therapeutics Inc. presented preclinical data for P-FVIII-101, a novel nonviral gene therapy being developed for the treatment of hemophilia A.
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DNA illustration
Drug Design, Drug Delivery & Technologies

Generation Bio develops immune-quiet DNA to be used as cargo in all programs

Oct. 19, 2023
Generation Bio Co. has announced a breakthrough in its nonviral genetic medicine platform with the development of a proprietary, novel DNA called immune-quiet DNA (iqDNA).


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3D illustration of a ribosome constructing messenger RNA molecules
Inflammatory

Immetas and GC Biopharma collaborate on mRNA therapeutics for autoimmune diseases

Oct. 13, 2023
Immetas Therapeutics Inc. and GC Biopharma Corp. have entered into a research collaboration to discover and develop novel mRNA therapeutics for the treatment of a broad range of autoimmune diseases. The collaboration combines Immetas’ proprietary platform for modulating innate immune pathways with GC Biopharma’s mRNA therapeutic and lipid nanoparticle (LNP) delivery platforms.
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