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Home » Keywords » T-cell exhaustion

Items Tagged with 'T-cell exhaustion'

ARTICLES

T cells attacking cancer cells
Immuno-oncology

SNX9 targeting: a promising strategy to prevent T-cell exhaustion and enhance antitumor immunity

Feb. 17, 2023
Tumor-specific CD8 T cells play a prominent role in antitumor immunity. However, these cells regularly enter a state of exhaustion due to chronic antigen stimulation within the tumor microenvironment.
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T cells

T-cell exhaustion is durable, but specific

Aug. 9, 2021
By Anette Breindl
It's a good news, bad news scenario for exhausted T cells in chronic infections. Multiple groups of investigators reported in the July 26, 2021, online issue of Nature Immunology that even after a chronic hepatitis C virus infection was cured, T cells that had become dysfunctional during the infection retained epigenetic "scars" that prevented them from becoming fully functional memory T cells.
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T cells

T-cell exhaustion is durable, but specific

July 28, 2021
By Anette Breindl
It's a good news, bad news scenario for exhausted T cells in chronic infections. Multiple groups of investigators reported in the July 26, 2021, online issue of Nature Immunology that even after a chronic hepatitis C virus infection was cured, T cells that had become dysfunctional during the infection retained epigenetic "scars" that prevented them from becoming fully functional memory T cells.
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