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Home » Keywords » endoplasmic reticulum stress

Items Tagged with 'endoplasmic reticulum stress'

ARTICLES

Gastrointestinal

NWD1 gene knockout tied to MASH-like phenotype in mice

March 17, 2025
The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress occurs in the liver, it triggers the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Previous reports found that NACHT and WD repeat domain containing 1 (NWD1) localized in the ER and mitochondria in neural stem/progenitor cells, but the significance of NWD1 outside the brain is not well known.
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T cells
Cancer

T cells use translational control to adapt to chronic stress

March 29, 2023
By Mar de Miguel
Secreting cytokines and killing tumor cells can be stressful for a T lymphocyte. In short adverse circumstances, these cells adapt to acute stress. If the situation persists, they activate a chronic stress response mechanism. According to a study by the Institute for Biomedical Research (IRB) in Barcelona, the cytoplasmic polyadenylation element-binding protein 4 (CPEB4) mediated this adaptation process.
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A microscopic image of liver tissue affected by metabolic dysfunction-associated steatotic liver disease.
Endocrine/Metabolic

Suppression of the somatotrophic axis controls liver damage but produces fibrosis

Dec. 14, 2022
By Mar de Miguel
Liver damage arrests growth mediated by the somatotroph axis, which prevents liver cell death and inflammation, but increases fibrosis in nonalcoholic fatty liver disease (NAFLD). The explanation for this effect could lie in the relationship between the activating transcription factor 3 (ATF-3) and insulin-like growth factor 1 (IGF-1), according to a study from the University of California at Berkeley.
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Gloved hand holding petri dish in lab

Nullifying necrosis: unfolded protein response inhibitors fight flesh-eating bacteria

Aug. 6, 2021
By Subhasree Nag
Researchers led by Emanuel Hanski at the Hebrew University of Jerusalem have identified a class of molecules that inhibit endoplasmic reticulum (ER) stress and could decrease mortality in mice infected with Streptococcus pyogenes, also known as the group A streptococci.
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