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Home » Keywords » tumor suppression

Items Tagged with 'tumor suppression'

ARTICLES

Astex gets $35M up front in expanded Merck deal targeting p53

Aug. 8, 2023
By Nuala Moran
Astex Pharmaceuticals Inc. is getting $35 million up front and up to $500 million per program as it extends its drug discovery collaboration with Merck & Co. Inc. to include small-molecule activators of the p53 tumor suppressor protein. The number of programs was not disclosed, but they will target forms of p53 that have lost their function as a result of cancer-induced mutations in the TP53 gene. The aim will be to override the mutation and restore the ability of the wild-type protein to bind DNA and perform its functions as a transcription factor.
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Biomarkers

CSMD1 expression is linked to poor prognosis in patients with glioma

Aug. 30, 2022
The prognostic role of complement inhibitor CSMD1 was assessed in 1,507 patients with glioma from three different datasets. Results of the bioinformatical analysis suggested that high expression of CSMD1 was associated with increased overall survival and disease-free survival, as well as lower tumor grade.
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Cancer cell and DNA

Diabetic foot ulcers hold clues to tumor suppression

May 16, 2022
By W. Todd Penberthy
New genomic research has increased the understanding of surprising links between diabetic foot ulcers and carcinomas.
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