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Home » Keywords » Sichuan University

Items Tagged with 'Sichuan University'

ARTICLES

Illustration of magnifying glass inspecting brain
Diagnostics

Toward in vivo imaging of α-synuclein aggregates using azocoumarin derivatives

May 21, 2025
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Being able to detect and monitor the aggregation of α-synuclein in situ could lead to more objective, earlier diagnosis of Parkinson’s disease as well as allow real-time monitoring of whether patients are responding to treatment.
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Gastric cancer
Cancer

Selective FGFR2 degrader with potent antitumor activity in gastric cancer models

Oct. 8, 2024
In research conducted at West China Hospital of Sichuan University and Chengdu University of Traditional Chinese Medicine, coupling of the pan-FGFR inhibitor erdafitinib with a CRBN binder led to a new series of fibroblast growth factor receptor (FGFR) degraders, with compound [I] identified as the lead candidate.
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Antibodies
Cancer

Novel anti-LIF antibody manifests relevant antitumor effect

Aug. 27, 2024
Leukemia inhibitory factor (LIF) is an IL-6 type cytokine involved in the inflammatory response, stem cell self-renewal and tumor progression, that binds to LIFR and gp130 on the cell surface. LIF is overexpressed in several types of cancer such as pancreatic, breast or prostate cancer and thus is considered a therapeutic target for the treatment of cancer.
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Drug R&D concept image.
Neurology/psychiatric

Novel articaine derivative has improved anesthetic, anti-inflammatory properties

July 30, 2024
DeepSA, an edit-based generative framework that utilizes deep simulated annealing (SA), was used to develop novel local anesthetics with multiple activities. Researchers from Sichuan University applied DeepSA to generate over 400 analogs of the local anesthetic articaine.
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Elderly woman and jigsaw puzzle
Neurology/psychiatric

Glutaminyl cyclase inhibition is effective in Parkinson’s disease

July 8, 2024
Targeting human glutaminyl-peptide cyclotransferase (QPCT) has emerged as a potential strategy in Alzheimer’s disease (AD). As the main substrates of this enzyme are involved in biological processes associated with neurodegenerative diseases, Parkinson’s disease (PD) and others may be other options to explore as well.
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Colorectal cancer 3D illustration
Cancer

Novel STAT3 inhibitor exerts antitumor activity in colorectal cancer models

June 27, 2024
Signal transducer and activator of transcription 3 (STAT3) plays a key role in cell proliferation observed in colorectal cancer (CRC), where up-regulation of STAT3 accelerates tumorigenesis and promotes metastasis.
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Inflammatory

RIPK1 inhibitor exhibits relevant antinecroptotic activity

Feb. 14, 2024
Receptor-interacting protein kinase 1 (RIPK1) regulates cell cycle and counteracts necroptosis, and is hence considered a target to watch in necroptosis-related conditions such as cancer or inflammatory diseases. Researchers from Sichuan University have reported on the discovery and structural optimization of a novel series of selective RIPK1 inhibitors intended for use in the treatment of inflammatory disorders.
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Leukemia illustration
Cancer

Antibody-drug conjugate shows efficacy in aggressive leukemia

Jan. 22, 2024
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that accounts for around 25% of ALL cases. In recent years, novel strategies have emerged to reduce the dependence on intensive chemotherapy or hematopoietic stem cell transplantation, but there is still a need for new options with better efficacy in this setting.
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Breast cancer illustration
Cancer

New G9a/GLP inhibitor is active in triple-negative breast cancer

Dec. 27, 2023
Researchers from Sichuan University and Chengdu Normal University have reported the discovery of novel G9a/GLP covalent inhibitors for the treatment of triple-negative breast cancer (TNBC).
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Illustration demonstrating muscle contraction in amyotrophic lateral sclerosis.
Biomarkers

Increased serum levels of cystatin C are associated with shorter survival in patients with ALS

Dec. 14, 2023
Researchers from West China Hospital of Sichuan University presented data from a study that aimed to investigate the associations between serum cystatin C (CysC) levels and the progression and survival of patients with amyotrophic lateral sclerosis (ALS).
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