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Tue, Jul 29, 2025

CAR T

Home » Topics » Immunotherapy » CAR T
  • B cell releasing antibodies
    July 23, 2025

    New preclinical data support further development of Orbital Therapeutics’ OTX-201

    Orbital Therapeutics Inc. has presented preclinical results supporting the development of OTX-201, a potential best-in-class in vivo CAR T therapy that comprises an optimized circular RNA encoding a CD19-targeted CAR delivered via targeted lipid nanoparticles.
  • Cancer gene therapy t cell
    July 14, 2025

    Two to tango but three to fight cancer

    Despite the increasing sophistication of anticancer therapies, many malignancies continue to evade treatment. T cells expressing chimeric antigen receptor (CAR) can effectively attack some tumors by recognizing antigens expressed on the tumor surface, but the therapy may prove ineffective if the target antigen is not abundant enough throughout the tumor.
  • Car t cells illustration
    July 8, 2025
    By Tamra Sami

    Researchers arm CAR T cells to fight solid tumors

    Aussie researchers have used CRISPR gene editing tools to “armor” chimeric antigen receptor (CAR) T cells to activate additional cancer-fighting proteins at the tumor site, enabling them to target cancer cells in solid tumors.
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